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Clinical Trials/NCT03414840
NCT03414840
Unknown
Not Applicable

Assessment of Change in Atherosclerotic Plaque by Serial CCTA

Yonsei University1 site in 1 country400 target enrollmentApril 1, 2018
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ConditionsCoronary Artery DiseaseHydroxymethylglutaryl-CoA Reductase InhibitorsCoronary Arteriosclerosis
DrugsAtorvastatin

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Coronary Artery Disease
Sponsor
Yonsei University
Enrollment
400
Locations
1
Primary Endpoint
Difference in percent change of total atheroma volume assessed by CCTA between statin-taking and statin-naïve group
Last Updated
7 years ago
OverviewInvestigatorsEligibility CriteriaOutcomesSitesSimilar Trials

Overview

Brief Summary

Assessment of Change in AtheROSclerotic Plaque by Serial CCTA (ACROSS) is designed as a prospective observational study which aim is to demonstrate the effect of statins on coronary atherosclerosis, assessed by quantitative analysis of CCTA.

Registry
clinicaltrials.gov
Start Date
April 1, 2018
End Date
October 31, 2020
Last Updated
7 years ago
Study Type
Observational
Sex
All

Investigators

Responsible Party
Principal Investigator
Principal Investigator

Hyuk-Jae Chang

Professor

Yonsei University

Eligibility Criteria

Inclusion Criteria

  • •Patients who underwent clinically indicated CCTA (index CCTA)
  • •Mild to moderate stenosis (25-69%) on CCTA
  • •≥1 clinical risk factors (Smoking, HTN, HDL\<40, Premature FHx, M ≥45, F ≥55) for CAD

Exclusion Criteria

  • •Acute coronary syndrome (unstable angina or MI)
  • •Positive (not equivocal) stress test
  • •Contraindications to statin

Outcomes

Primary Outcomes

Difference in percent change of total atheroma volume assessed by CCTA between statin-taking and statin-naïve group

Time Frame: 24 months

Patients indicated with statin therapy according to current guideline will receive atorvastatin.

Secondary Outcomes

  • Change of total atheroma volume at 24 months compared with baseline total atheroma volume(24 months)

Study Sites (1)

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