NCT03414840Unknown不适用
Assessment of Change in Atherosclerotic Plaque by Serial CCTA
适应症
相关药物
试验速览
- 阶段
- 不适用
- 入组人数
- 400
- 试验地点
- 1
- 主要终点
- Difference in percent change of total atheroma volume assessed by CCTA between statin-taking and statin-naïve group
研究概览
简要总结
Assessment of Change in AtheROSclerotic Plaque by Serial CCTA (ACROSS) is designed as a prospective observational study which aim is to demonstrate the effect of statins on coronary atherosclerosis, assessed by quantitative analysis of CCTA.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 19 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients who underwent clinically indicated CCTA (index CCTA)
- •Mild to moderate stenosis (25-69%) on CCTA
- •≥1 clinical risk factors (Smoking, HTN, HDL<40, Premature FHx, M ≥45, F ≥55) for CAD
排除标准
- •Acute coronary syndrome (unstable angina or MI)
- •Positive (not equivocal) stress test
- •Contraindications to statin
结局指标
主要结局
Difference in percent change of total atheroma volume assessed by CCTA between statin-taking and statin-naïve group
时间窗: 24 months
Patients indicated with statin therapy according to current guideline will receive atorvastatin.
次要结局
- Change of total atheroma volume at 24 months compared with baseline total atheroma volume(24 months)
研究者
Hyuk-Jae Chang
Professor
Yonsei University
研究点 (1)
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