A Long-term Observational Study on the Efficacy of SSRIs Pharmacotherapy or Combined Treatment(SSRIs Pharmacotherapy + CBT) in Panic Disorder Patients
试验速览
- 阶段
- 不适用
- 入组人数
- 110
- 试验地点
- 1
- 主要终点
- PDSS
研究概览
简要总结
It is known that the treatment of panic disorder with medication and psychotherapy are both effective. Representative as a treatment for panic disorder, Selective serotonin reuptake inhibitors (SSRIs) are recommended as first-line treatment of panic disorder. In general, the initial reaction rate of panic disorder medication known to be frequently stopped early recurrence 70-80% It's too early, it is recommended that the duration of drug treatment for at least one year to be long-lasting. But whether it is appropriate for the duration of drug treatment to maintain a certain extent remains controversial, and maintain the medication for more than one year, even if the long-term effects known to be approximately 50% less than beyond being negative when remission based. Meanwhile, the typical method for the treatment of panic disorder psychology, cognitive behavioral therapy (Cognitive behavioral therapy) and looked comparable to the effect of the drug in the treatment of the known, especially in recent years when the combined treatment with medication can increase the long-term treatment of sexual reported that there's has been the subject of attention.
But prospectively compare the long-term effects of these two treatments, research, especially the research about the long-term effects of the combined treatment with the drug treatment of panic disorder is very low, and almost nil is Researchers, drug treatment and the effect of the combined treatment in patients with panic disorder over two years prospective study to compare the plans were. And verification, the researchers performed only through this study by comparing the long-term effects of the combined treatment with medication combined treatment of medication to be more effective than if the reaction to the long-term treatment of panic disorder that can affect the clinical and biological factors navigate to evaluate them. In addition, long-term observational study, panic disorder patients' subjective quality of life actually improved to some extent on the map together proven to.
详细描述
Panic disorder SSRI medication and long-term effects of the combined treatment on the Hamilton Rating Scale more effective treatment compared with the Scale for Anxiety (HAM-A), Clinical Psychology, I try to find the law. Drug and combination therapy of panic disorder from affecting the long-term effects on clinical (demographic and economic Factors), and to check for navigation and biological factors. - Improved quality of life to some extent due to the long-term treatment of patients with panic disorder, if you want to check
2.3 Expected Effects Panic disorder in a comparative study of the long-term effects of the combined treatment with SSRI medication until now very rare, and most of the research to target Westerners, Asians to study is almost wholly lacking. Also to investigate the nature of the clinical course of panic disorder, long-term study also little or no sleep. Elapsed for the treatment of long-term treatment of panic disorder and its impact on various clinical variables to be able to figure out if, through the analysis of the results of this study, the future could be a very useful background material, used in the development of clinical care guidelines is expected. Leading researchers in various studies for panic disorder at home and abroad, and also, therefore, the results obtained in this research is very useful in the pathogenesis and in the treatment of panic disorder is expected. The results of this study will be introduced in the Domestic Society and International Society, will finally be published in major journals of SCI related.
3 Research plan 3.1 Research information and how to
- The selection of subjects Diagnosis by the DSM-IV diagnostic criteria for major panic attacks in patients with disabilities will be conducted by a clinical psychologist or psychiatrist: Mini International Neuropsychiatric Interview Plus (MINI-plus) of structured skilled diagnostic tool.
In the case of patients who were taking medication Airlines sulfur existing at least 2 weeks (hydrochloric acid flu Jade Satin scheduled to participate in a study of the existing 4 weeks) and stop taking the drug. All other prescription non-drug (herbal medicine), forbids smoking within 24 hours before the test, caffeine drink, drinking is prohibited in the state to proceed with a test is scheduled.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 20 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Outpatients with panic disorder at the SMC
- •PD patients who agree to participate in the clinical study
- •PD patients who are over 20 years old
排除标准
- •PD patients who have either severe medical illnesses or other psychiatric illnesses
- •PD patients who are pregnant, or lactating
- •PD patients who have suicidal idea
结局指标
主要结局
PDSS
时间窗: one year
次要结局
未报告次要终点