Cerebral Blood Perfusion Changes After General Anesthesia for Craniotomy

Not Applicable

Completed

• Conditions: Surgery; Brain Neoplasms; Hyperemia
• Interventions: Device: Transcranial Doppler (TCD); Procedure: Radial artery catheterization; Procedure: jugular venous bulb catheterization; Procedure: Tumor removal surgery under general anesthesia; Procedure: Abdominal surgery under general anesthesia

• Registration Number: NCT01642147
• Lead Sponsor: Huashan Hospital

Brief Summary

Few studies look into cerebral blood flow (CBF) changes during emergence from general anesthesia for craniotomy. The purpose of this study is to demonstrate CBF changes during emergence from general anesthesia for craniotomy, through monitoring blood oxygen saturation of jugular vein bulb and transcranial Doppler.

Detailed Description

30 patients undergoing selective craniotomy (craniotomy group) for supratentorial brain tumor removal and 30 patients undergoing selective abdominal surgery (abdominal surgery group) are planned to be enrolled in the study. Mean blood flow velocity in middle cerebral artery (Vmca), mean arterial pressure (MAP), blood oxygen saturation of jugular vein bulb (SjvO2) (only measured in craniotomy group)and arterial CO2 partial pressure (PaCO2) will be measured before general anesthesia, at tracheal extubation, and 30,60, 90, 120 min after extubation in both groups.

Study Timeline

• Study First Submitted: 2012-07-08
• Study First Submitted QC: 2012-07-12
• Study First Posted: 2012-07-17
• Study Start: 2012-11
• Primary Completion: 2013-01
• Study Completion: 2013-01
• Results First Submitted: 2013-03-09
• Results First Submitted QC: 2013-03-09
• Results First Posted: 2013-04-23
• Status Verified: 2013-05
• Last Update Submitted: 2013-05-15
• Last Update Posted: 2013-06-24

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• American Society of Anesthesia (ASA) physical status I or II
• Scheduled for selective supratentorial tumor removal surgery or major abdominal surgery.

Exclusion Criteria

• Patients with evidence of systemic hypertension, intracranial hypertension, cerebrovascular diseases, other coexisting medical conditions likely to affect cerebral autoregulation.
• Preoperatively planned delayed tracheal extubation.
• Pregnant or nursing women

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Patients undergoing craniotomy	Tumor removal surgery under general anesthesia	Patients undergoing craniotomy who are scheduled for selective supratentorial tumor removal surgery will be randomly chosen and recruited. Transcranial Doppler (TCD) measures,jugular venous bulb catheterization, radial artery catheterization, and tumor removal surgery under general anesthesia will be performed.
Patients undergoing craniotomy	Transcranial Doppler (TCD)	Patients undergoing craniotomy who are scheduled for selective supratentorial tumor removal surgery will be randomly chosen and recruited. Transcranial Doppler (TCD) measures,jugular venous bulb catheterization, radial artery catheterization, and tumor removal surgery under general anesthesia will be performed.
Patients undergoing abdominal surgery	Radial artery catheterization	Randomly chosen patients undergoing selective abdominal surgery. Transcranial Doppler (TCD) measures,radial artery catheterization, and major abdominal surgery under general anesthesia will be performed.
Patients undergoing abdominal surgery	Abdominal surgery under general anesthesia	Randomly chosen patients undergoing selective abdominal surgery. Transcranial Doppler (TCD) measures,radial artery catheterization, and major abdominal surgery under general anesthesia will be performed.
Patients undergoing craniotomy	jugular venous bulb catheterization	Patients undergoing craniotomy who are scheduled for selective supratentorial tumor removal surgery will be randomly chosen and recruited. Transcranial Doppler (TCD) measures,jugular venous bulb catheterization, radial artery catheterization, and tumor removal surgery under general anesthesia will be performed.
Patients undergoing craniotomy	Radial artery catheterization	Patients undergoing craniotomy who are scheduled for selective supratentorial tumor removal surgery will be randomly chosen and recruited. Transcranial Doppler (TCD) measures,jugular venous bulb catheterization, radial artery catheterization, and tumor removal surgery under general anesthesia will be performed.
Patients undergoing abdominal surgery	Transcranial Doppler (TCD)	Randomly chosen patients undergoing selective abdominal surgery. Transcranial Doppler (TCD) measures,radial artery catheterization, and major abdominal surgery under general anesthesia will be performed.

Primary Outcome Measures

Name	Time	Method
Mean Blood Flow Velocity in Middle Cerebral Artery	120min after extubation
Oxygen Saturation of Jugular Venous Bulb	120min after extubation

Trial Locations

Locations (1)

Huashan Hospital; 🇨🇳 Shanghai, Shanghai, China