Cerebral Hyperemia During Emergence From General Anesthesia for Craniotomy of Patients With Brain Tumor
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Mean Blood Flow Velocity in Middle Cerebral Artery
研究概览
简要总结
Few studies look into cerebral blood flow (CBF) changes during emergence from general anesthesia for craniotomy. The purpose of this study is to demonstrate CBF changes during emergence from general anesthesia for craniotomy, through monitoring blood oxygen saturation of jugular vein bulb and transcranial Doppler.
详细描述
30 patients undergoing selective craniotomy (craniotomy group) for supratentorial brain tumor removal and 30 patients undergoing selective abdominal surgery (abdominal surgery group) are planned to be enrolled in the study. Mean blood flow velocity in middle cerebral artery (Vmca), mean arterial pressure (MAP), blood oxygen saturation of jugular vein bulb (SjvO2) (only measured in craniotomy group)and arterial CO2 partial pressure (PaCO2) will be measured before general anesthesia, at tracheal extubation, and 30,60, 90, 120 min after extubation in both groups.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 25 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •American Society of Anesthesia (ASA) physical status I or II
- •Scheduled for selective supratentorial tumor removal surgery or major abdominal surgery.
排除标准
- •Patients with evidence of systemic hypertension, intracranial hypertension, cerebrovascular diseases, other coexisting medical conditions likely to affect cerebral autoregulation.
- •Preoperatively planned delayed tracheal extubation.
- •Pregnant or nursing women
研究组 & 干预措施
Patients undergoing craniotomy
Patients undergoing craniotomy who are scheduled for selective supratentorial tumor removal surgery will be randomly chosen and recruited.
Transcranial Doppler (TCD) measures,jugular venous bulb catheterization, radial artery catheterization, and tumor removal surgery under general anesthesia will be performed.
干预措施: Transcranial Doppler (TCD) (Device)
Patients undergoing craniotomy
Patients undergoing craniotomy who are scheduled for selective supratentorial tumor removal surgery will be randomly chosen and recruited.
Transcranial Doppler (TCD) measures,jugular venous bulb catheterization, radial artery catheterization, and tumor removal surgery under general anesthesia will be performed.
干预措施: jugular venous bulb catheterization (Procedure)
Patients undergoing craniotomy
Patients undergoing craniotomy who are scheduled for selective supratentorial tumor removal surgery will be randomly chosen and recruited.
Transcranial Doppler (TCD) measures,jugular venous bulb catheterization, radial artery catheterization, and tumor removal surgery under general anesthesia will be performed.
干预措施: Tumor removal surgery under general anesthesia (Procedure)
Patients undergoing craniotomy
Patients undergoing craniotomy who are scheduled for selective supratentorial tumor removal surgery will be randomly chosen and recruited.
Transcranial Doppler (TCD) measures,jugular venous bulb catheterization, radial artery catheterization, and tumor removal surgery under general anesthesia will be performed.
干预措施: Radial artery catheterization (Procedure)
Patients undergoing abdominal surgery
Randomly chosen patients undergoing selective abdominal surgery. Transcranial Doppler (TCD) measures,radial artery catheterization, and major abdominal surgery under general anesthesia will be performed.
干预措施: Transcranial Doppler (TCD) (Device)
Patients undergoing abdominal surgery
Randomly chosen patients undergoing selective abdominal surgery. Transcranial Doppler (TCD) measures,radial artery catheterization, and major abdominal surgery under general anesthesia will be performed.
干预措施: Radial artery catheterization (Procedure)
Patients undergoing abdominal surgery
Randomly chosen patients undergoing selective abdominal surgery. Transcranial Doppler (TCD) measures,radial artery catheterization, and major abdominal surgery under general anesthesia will be performed.
干预措施: Abdominal surgery under general anesthesia (Procedure)
结局指标
主要结局
Mean Blood Flow Velocity in Middle Cerebral Artery
时间窗: 120min after extubation
Oxygen Saturation of Jugular Venous Bulb
时间窗: 120min after extubation
次要结局
未报告次要终点
研究者
Xiao-Yu Yang
Principal Investigator
Huashan Hospital