Cerebral Hyperemia During Emergence From General Anesthesia for Craniotomy of Patients With Brain Tumor
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Brain Neoplasms
- Sponsor
- Huashan Hospital
- Enrollment
- 60
- Locations
- 1
- Primary Endpoint
- Mean Blood Flow Velocity in Middle Cerebral Artery
- Status
- Completed
- Last Updated
- 12 years ago
Overview
Brief Summary
Few studies look into cerebral blood flow (CBF) changes during emergence from general anesthesia for craniotomy. The purpose of this study is to demonstrate CBF changes during emergence from general anesthesia for craniotomy, through monitoring blood oxygen saturation of jugular vein bulb and transcranial Doppler.
Detailed Description
30 patients undergoing selective craniotomy (craniotomy group) for supratentorial brain tumor removal and 30 patients undergoing selective abdominal surgery (abdominal surgery group) are planned to be enrolled in the study. Mean blood flow velocity in middle cerebral artery (Vmca), mean arterial pressure (MAP), blood oxygen saturation of jugular vein bulb (SjvO2) (only measured in craniotomy group)and arterial CO2 partial pressure (PaCO2) will be measured before general anesthesia, at tracheal extubation, and 30,60, 90, 120 min after extubation in both groups.
Investigators
Xiao-Yu Yang
Principal Investigator
Huashan Hospital
Eligibility Criteria
Inclusion Criteria
- •American Society of Anesthesia (ASA) physical status I or II
- •Scheduled for selective supratentorial tumor removal surgery or major abdominal surgery.
Exclusion Criteria
- •Patients with evidence of systemic hypertension, intracranial hypertension, cerebrovascular diseases, other coexisting medical conditions likely to affect cerebral autoregulation.
- •Preoperatively planned delayed tracheal extubation.
- •Pregnant or nursing women
Outcomes
Primary Outcomes
Mean Blood Flow Velocity in Middle Cerebral Artery
Time Frame: 120min after extubation
Oxygen Saturation of Jugular Venous Bulb
Time Frame: 120min after extubation