Cerebral Blood Perfusion Changes After General Anesthesia for Craniotomy

Not Applicable

Completed

• Conditions: Surgery; Brain Neoplasms; Hyperemia

• Registration Number: NCT01642147
• Lead Sponsor: Huashan Hospital

Brief Summary

Few studies look into cerebral blood flow (CBF) changes during emergence from general anesthesia for craniotomy. The purpose of this study is to demonstrate CBF changes during emergence from general anesthesia for craniotomy, through monitoring blood oxygen saturation of jugular vein bulb and transcranial Doppler.

Detailed Description

30 patients undergoing selective craniotomy (craniotomy group) for supratentorial brain tumor removal and 30 patients undergoing selective abdominal surgery (abdominal surgery group) are planned to be enrolled in the study. Mean blood flow velocity in middle cerebral artery (Vmca), mean arterial pressure (MAP), blood oxygen saturation of jugular vein bulb (SjvO2) (only measured in craniotomy group)and arterial CO2 partial pressure (PaCO2) will be measured before general anesthesia, at tracheal extubation, and 30,60, 90, 120 min after extubation in both groups.

Study Timeline

• Study First Submitted: 2012-07-08
• Study First Submitted QC: 2012-07-12
• Study First Posted: 2012-07-17
• Study Start: 2012-11
• Primary Completion: 2013-01
• Study Completion: 2013-01
• Results First Submitted: 2013-03-09
• Results First Submitted QC: 2013-03-09
• Results First Posted: 2013-04-23
• Status Verified: 2013-05
• Last Update Submitted: 2013-05-15
• Last Update Posted: 2013-06-24

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• American Society of Anesthesia (ASA) physical status I or II
• Scheduled for selective supratentorial tumor removal surgery or major abdominal surgery.

Exclusion Criteria

• Patients with evidence of systemic hypertension, intracranial hypertension, cerebrovascular diseases, other coexisting medical conditions likely to affect cerebral autoregulation.
• Preoperatively planned delayed tracheal extubation.
• Pregnant or nursing women

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Mean Blood Flow Velocity in Middle Cerebral Artery	120min after extubation
Oxygen Saturation of Jugular Venous Bulb	120min after extubation

Trial Locations

Locations (1)

Huashan Hospital; 🇨🇳 Shanghai, Shanghai, China