Beneficial Effects of Self-hypnosis/Self-care for Chronic Pain Patients : a MRI and EEG Study
- Conditions
- Chronic Pain
- Interventions
- Behavioral: Self-hypnosis/self-care
- Registration Number
- NCT04263324
- Lead Sponsor
- University of Liege
- Brief Summary
Chronic pain concerns one in four adults in Belgium. Fibromyalgia is an example of chronic pain and is characterized by diffused and migrant musculo-tendinous pain localized in the limbs and at an axial level. The technological improvement in neuroimaging allowed to improve, at a cerebral level, the identification of the structural and the functional characteristics of this clinical entity. Studies indicated a modification in cerebral morphometry showing an alteration of white and grey matter in the anterior cingulate cortex, orbitofrontal lateral cortex, cerebellum, basal ganglia, insula, secondary somatosensory cortex, thalamus, amygdala, putamen, superior temporal gyrus and periaqueductal grey matter. At a functional level, studies show un alteration in the connectivity of the default mode network, an atrophy of zones implicated in nociception and an increased activation of zone implicated in response to a nociceptive stimulus.
Nowadays, researchers are interested in finding out the beneficial effects of non-pharmacological techniques to improve de well-being of patients with chronic pain. Hypnosis is one of these techniques that has already proven to be successful in decreasing pain and improving global quality of life. Nevertheless, to our knowledge, no study has been conducted to understand the impact of hypnosis upon the cerebral functioning of these patients. Therefore, the aim of this study is to understand the impact of a 6 months self-hypnosis/self-care learning program upon the structural and functional functioning of the brain by means of functional magnetic resonance imagery (fMRI) and electroencephalography (EEG).
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 60
- Major
- Fluency in French
- Fibromyalgia diagnosis
- Neurologic disorder
- Psychiatric disorder
- Drug addiction
- Alcoholism
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Self-hypnosis/self-care group Self-hypnosis/self-care It is a 7-months 2 hours-session (1 session per month) of self-hypnosis/self-care learning. Participants are given strategies to learn self-care (knowing their needs, self-respect, communication etc.), each strategy is discussed for participant to understand them and thus apply them correctly in daily life. An hypnosis exercise is conducted at the end of each session. A CD with the audiotaped hypnosis exercise is given to each patient so that they can practice also every day.
- Primary Outcome Measures
Name Time Method Change in pain description Day 0 (first meeting with the doctor), up to 5 months (before the intervention), up to 12 months (after the intervention) The impact of self-hypnosis/self-care on pain description will be assessed by means of a Visual Analogue Scale (VAS). Scale ranging from 0 (no pain) to 10 (worst pain).
Change in pain disability Day 0 (first meeting with the doctor), up to 5 months (before the intervention), up to 12 months (after the intervention) The impact of self-hypnosis/self-care on pain disability will be assessed by means of the "Pain Disability Index" (PDI, Tait et al., 1990). Scale ranging from 0 (no difficulties) to 10 (a lot of difficulties).
Change in health status Day 0 (first meeting with the doctor), up to 5 months (before the intervention), up to 12 months (after the intervention) The impact of Self-hypnosis/self-care on global health status will be assessed by means of a Visual Analogue Scale (VAS). Scale ranging from 0 (worst health status) to 100 (best health status).
Change in quality of life Day 0 (first meeting with the doctor), up to 5 months (before the intervention), up to 12 months (after the intervention) The impact of self-hypnosis/self-care on the quality of life will be assessed by means of the "Short Form-36"(SF-36; Ware et al., 1988). Each item is balanced to obtain a score between 0 (worst quality) to 100 (maximum quality).
Change in sleep difficulties Day 0 (first meeting with the doctor), up to 5 months (before the intervention), up to 12 months (after the intervention) The impact of self-hypnosis/self-care upon the severity of insomnia will be assessed by means of the "Insomnia Severity Index" (Morin et al., 2001). Scale ranging from 0 (none) to 4 (very severe).
Change in locus of control Day 0 (first meeting with the doctor), up to 5 months (before the intervention), up to 12 months (after the intervention) The impact of self-hypnosis/self-care on the locus of control will be assessed my means og the "Multidimensional Health Locus of Control" (MHLC, Wallston et al., 1978). Scale ranging from 1 (no agreement) to 4 (agreement).
Change in anxiety Day 0 (first meeting with the doctor), up to 5 months (before the intervention), up to 12 months (after the intervention) The impact of self-hypnosis/self-care on anxiety will be assessed by means of the subtest "anxiety" of the Hospital Anxiety and Depression Scale (HADS, Zigmond \& Snaith, 1983). Scale ranging from 0 (never) to 4 (always).
Change in depression Day 0 (first meeting with the doctor), up to 5 months (before the intervention), up to 12 months (after the intervention) The impact of self-hypnosis/self-care on depression will be assessed by means of the subtest "anxiety" of the Hospital Anxiety and Depression Scale (HADS, Zigmond \& Snaith, 1983). Scale ranging from 0 (never) to 4 (always).
Change in attitudes and beliefs about pain Day 0 (first meeting with the doctor), up to 5 months (before the intervention), up to 12 months (after the intervention) The impact of self-hypnosis/self-care on the attitudes and beliefs about pain will be assessed my means of the "Survey of Pain Attitudes" (SOPA, Jensen \& Karoly, 1987). Scale ranging from 0 (totally wrong) to 10 (totally right).
Change of the impact of pain Day 0 (first meeting with the doctor), up to 5 months (before the intervention), up to 12 months (after the intervention) The impact of self-hypnosis/self-care on the impact of pain in individual's life, quality of social support and general activity, will be assessed my means of the "Multidimensional Pain Index" (PDI, Kerns et al., 1985). Scale ranging from 0 (none) to 6 (a lot).
Change in generic health Day 0 (first meeting with the doctor), up to 5 months (before the intervention), up to 12 months (after the intervention) The impact of self-hypnosis/self-care on generic health will be assessed by the "EuroQol 5 Dimensions" questionnaire (EQ-5D, Health Policy, 1990). Scale ranging from 1 (no problems) to 3 (extreme problems).
Change in physical activity Day 0 (first meeting with the doctor), up to 5 months (before the intervention), up to 12 months (after the intervention) The impact of self-hypnosis/self-care on the physical activity will be assessed by means of the International Physical Activity Questionnaire (Craig et al., 2003). Participants have to describe the amount of low to intense physical activity they did over a period of 7 days.
Motivation to change Day 0 (first meeting with the doctor), up to 5 months (before the intervention), up to 12 months (after the intervention) The impact of self-hypnosis/self-care on the motivation to change will be assessed by means of the "University of Rhode Island Change Assessment" (URICA, DiClemente et al., 1990). Scale ranging from 1 (no agreement) to 5 (agreement).
Impact on return-to-work Day 0 (first meeting with the doctor), up to 5 months (before the intervention), up to 12 months (after the intervention) For participants who continued to work at time of inclusion, the "Work Design Questionnaire" (WDQ, Morgeson \& Hymphrey, 2006) will be administered. Scale ranging from 0 (not at all) to 5 (exactly).
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Hospital University of Liège
🇧🇪Liège, Belgium