A pilot study of potential role of Liver X receptor in nonalcoholic steatohepatitis
Not Applicable
Recruiting
- Conditions
- Diseases of the digestive system
- Registration Number
- KCT0000900
- Lead Sponsor
- Hanyang University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 60
Inclusion Criteria
Inclusion criteria
-20 years to 70 years
-clinically diagnosed for nonalcoholic liver disease
-diagnosed for fatty liver by ultrasonography or CT
-serum ALT or AST is greater than 40 IU/L
Exclusion Criteria
Exclusion criteria
-alcohol intake (> 140g/week in man, >70g/week in woman)
-diabetes requiring insulin therapy
-immuno-suppressive therapy (ex. steroid)
-serum creatinine of 5.0 mg/dL or greater
-hepatitis B as defined by presence of hepatitis B surface antigen
-hepatitis C as defined by presence of HCV-RNA or positive hepatitis C antibody
-any suspicion of other liver disease such as autoimmune hepatitis
Study & Design
- Study Type
- Observational Study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method comparison of LXR expression between NASH, NAFLD and control group
- Secondary Outcome Measures
Name Time Method 1. clinical characteristics as expression level of LXR;2. correlation of NPC1L1, ABCG5/8, ABCA1, SREBP-1C expression;3. compare the previous studies with animals and this study with human liver samples