Evaluation of Soybean Peptides Product on Regulation of Blood Pressure Effect by Clinical Trial
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- The soy bean peptides anti-hypertensive measure blood pressure (SBP and DBP)
研究概览
简要总结
This is the report to assess supplementation with soybean peptides on blood pressure among people with mild hypertension. Overall, soybean peptide consumption for 8 weeks could successfully reduce mean diastolic and systolic BP through the suppression of Angiotensin-converting enzyme (ACE) linked to downstream suppression of angiotensin II formation, which further decreases the sympathetic outflow that leads to hypertension.
详细描述
This is the report to assess supplementation with soybean peptides on blood pressure among people with mild hypertension. Thirty subjects with systolic blood pressure (SBP) between 120 and 159 mm Hg and/or diastolic blood pressure (DBP) between 80 and 99 mm Hg were randomized to ingest 2 bags of soybean peptides or placebo per day for 8 weeks of a stage. Anthropometric measurements (blood pressure, body weight, body fat) and blood biochemical markers including fasting blood glucose (FBG), albumin, total cholesterol (TC), triglyceride (TG), HDL-C, LDL-C, creatinine (Cr), blood urea nitrogen (BUN), AST, ALT) were examined every four weeks.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Prevention
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 20 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Eligible subjects were untreated hypertensive men or women aged between 20 and 80 years old with SBP between 120 and 159 mmHg and/or DBP between 80 and 99 mmHg as measured in a sitting position
排除标准
- •Subjects were excluded if they had a history of major cardiovascular disease or severe liver dysfunction;
- •Diastolic blood pressure ≥ 100 mmHg or Systolic blood pressure ≥ 160 mmHg;
- •Alcoholic;
- •US-controlled diabetics;
- •Stoke in past one year;
- •Mental diseases or melancholia;
- •Pregnancy or breast-feeding a child;
- •Renal dysfunction;
- •Allergic to Soybean peptides.
结局指标
主要结局
The soy bean peptides anti-hypertensive measure blood pressure (SBP and DBP)
时间窗: 8 weeks
values chang of systolbbic and diastolic BPs between before to after 8 weeks
次要结局
未报告次要终点
研究者
You-Cheng Shen
School of Health Diet and Industry Managment
Chung Shan Medical University