Brain Death: Inflammatory Response, Apoptosis, and Endotoxin Tolerance
Completed
- Conditions
- Brain Death
- Interventions
- Procedure: Muscle biopsy
- Registration Number
- NCT00615225
- Lead Sponsor
- Delafontaine Hospital
- Brief Summary
We hypothesized that brain death is associated with an early systemic inflammatory response, possibly combined with activation of apoptotic cell death, two events that may contribute to induce rapid organ dysfunction. In this study of brain-dead donors and controls, we assayed plasma cytokines and soluble factors, investigated plasma endotoxin levels as a triggering factor for inflammation, measured ex vivo cytokine production by blood leukocytes to determine whether immunosuppression occurred after brain death, and examined skeletal muscle biopsies to look for evidence of inflammation and increased apoptosis in peripheral tissue.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- Not specified
Inclusion Criteria
- All brain dead patients whatever the cause (cardiac arrest, stroke, head trauma)
Exclusion Criteria
- Age < 18years
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Brain dead patients Muscle biopsy All patients meeting criteria for brain death Volunteers having hip surgery Muscle biopsy Patients undergoing hip surgery for degenerative non-inflammatory hip disease
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (3)
Liege Hospital
🇧🇪Liege, Belgium
Delafontaine Hospital
🇫🇷Saint Denis, France
Tenon Hospital
🇫🇷Paris, France