DRKS00015159已完成不适用
Influence of somatic mutational status of DNA repair genes on the clinical course in men with High risk-prostate cancer - a prospective biomarker study
niversitätsklinikum Heidelberg Nationales Centrum für Tumorerkrankungen (NCT) Medizinische Onkologie und Urologische Klinik0 个研究点目标入组 197 人开始时间: 2019年2月25日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 197
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- one 至 one（—）
- 性别
- Male
入选标准
- •Histological subtype: adenocarcinoma of the prostate without neuroendocrine differentiation
- •age at disease onset =50 years and/or
- •M1 (primary metastasized; every Gleason score, every T, every N, every M) and/or
- •Gleason Score 9 or 10 (every T, every M) and/or
- •Gleason Score 8 in combination with =pT3 or N1 or PSA =20 ng/ml and/or
- •early tumor recurrence or persistence after local therapy (Prostatectomy or Radiotherapy of the prostate) within =12 months and with high PSA doubling time of =3 months and/or
- •early development of castrations resistance of the prostate cancer under first line treatment with ADT alone or combination of ADT with Docetaxel or Abiraterone
- •no contraindication for approved treatments
- •ECOG: 0-1
- •availability of tumor tissue in good quality for DNA sequencing
- •Complete clinical documentation (PSA at diagnosis, histology, Gleason Score, TNM-Score, course of treatment, course of PSA, radiological reports of all scans since the time of diagnosis
排除标准
- •pre-existing psychiatric disorder
- •other active malignant diseases
- •non legally competent or incapacitated patients
- •patients, who refuse to undergo systemic treatments
研究者
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