iquid Biopsies for minimally invasive Detection of Acute Rejectio
Completed
- Conditions
- orgaantransplantatiegraft rejectiontransplant rejection
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 450
Inclusion Criteria
Adult kidney transplant recipients (>= 18 years of age) receiving a kidney
transplant of either a living or deceased donor in the Erasmus MC.
Exclusion Criteria
Below 18 years of age
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Primary endpoint of this explorative study is the ability to identify kidney<br /><br>allograft rejection by markers in blood and/or urine; i.e. level of dd-cfDNA,<br /><br>presence of specific nucleosome variants, circulating endothelial cells and the<br /><br>presence of EVs. Therefore, the outcome of the proposed markers will be<br /><br>correlated with the currently used methods which are the kidney biopsy, serum<br /><br>creatinine and urinary protein concentrations.</p><br>
- Secondary Outcome Measures
Name Time Method <p>Secondary the proposed markers will be correlated with the urinary<br /><br>concentrations of CXCL9 and CXCL10, which are promising upcoming non-invasive<br /><br>markers for allograft rejection. In exploratory analyses, we will try to<br /><br>identify the best marker or combination of markers to diagnose kidney<br /><br>transplant rejection. </p><br>