Circadian Rhythms and Sleep in Familial Delayed Sleep Phase Syndrome (DSPS) and Advanced Sleep Phase Syndrome (ASPS)
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Circadian Rhythm Sleep Disorder
- Sponsor
- Northwestern University
- Enrollment
- 156
- Locations
- 1
- Primary Endpoint
- Sleep
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
The purpose of this study is to determine the properties of circadian rhythms and sleep propensity in familial advanced and delayed sleep phase syndrome (DSPS).
Detailed Description
BACKGROUND: Tremendous progress in the past few years has led to the identification of several circadian clock genes. This now makes it possible to determine how alterations of human circadian clock genes and their expression could lead to differences in circadian and sleep/wake cycle phenotypes. Of particular interest for understanding genetics of the human circadian system are individuals with sleep phase disorders, such as DSPS and advanced sleep phase syndrome (ASPS), because recent studies indicate a genetic basis for these disorders. While it is assumed that both ASPS and DSPS are disorders of circadian timing, little is known about how the circadian clock system, or its interaction with sleep processes, are affected in these individuals. DESIGN NARRATIVE: Participants will complete questionnaires and actigraphy to determine sleep patterns and quality.
Investigators
Phyllis Zee
Benjamin and Virginia T. Boshes Professor of Neurology
Northwestern University
Eligibility Criteria
Inclusion Criteria
- Not provided
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Sleep
Time Frame: 1 night
Assessment of sleep parameters
Secondary Outcomes
- Circadian Timing(3 days)