Wrist Cartilage - High Resolution in Vivo MR T2 Mapping- a Feasibility Study

• Conditions: Osteoarthritis

• Registration Number: NCT00669201
• Lead Sponsor: Sheba Medical Center

Brief Summary

Purpose:Evaluate the feasibility of T2 cartilage mapping on MRI of the wrist and correlate with T2 mapping of knee cartilage.

Study protocol: Phase 1. 10 healthy volunteers, Phase 2. 10 volunteers with osteoarthritis of the wrist, Phase 3. 50 patients for studies for routine MR of the wrist.

MRI protocol: 3 T unit((Signa EXITE HDx),T1, T2 and T2 mapping sequences on axial and coronal orientation.

Detailed Description

Not available

Study Timeline

• Study Start: 2007-12
• Status Verified: 2008-04
• Study First Submitted: 2008-04-28
• Study First Submitted QC: 2008-04-29
• Last Update Submitted: 2008-04-29
• Study First Posted: 2008-04-30
• Last Update Posted: 2008-04-30

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 70

Inclusion Criteria

• Phase 1. Age:18-40
• Phase 2: No age limit, known OA on pre-existing X-rays
• Phase 3: No age limit, routine MRI of the wrist

Exclusion Criteria

• Phase 1, 2: wrist trauma/surgery
• All phases: any contraindication for MR: eg metals, claustrophobia, etc.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
wrist bone cartilage thickness can be measured and stratification can be observed on T2 mapping with correlation to T2 mapping of the knee cartilage	Within MRI completion (20 minutes)

Trial Locations

Locations (2)

Sheba Medical Center, Diagnostic Imaging Dept; 🇮🇱 Tel Hashomer, Israel

Sheba Medical Center , Diagnostic Imaging Dept; 🇮🇱 Tel Hashomer, Israel