Dynamic 3D MRI for detection, quantification and evaluation of small bowel motility
- Conditions
- bowel movementGastro-intestinal motility10017969
- Registration Number
- NL-OMON45985
- Lead Sponsor
- Academisch Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 42
Healthy, human volunteers who are willing to undergo minimal bowel preparation and magnetic resonance imaging (MRI) and who are willing to give informed consent.
An age of less than 18 years or more than 45 years, subjects who were unable to give informed consent, the inability to hold breath for 25 seconds, history of abdominal surgery, gastrointestinal diseases or current gastrointestinal symptoms. Furthermore exclusion criteria are (relative) contraindications to undergo MRI; pacemakers, claustrophobia and pregnancy. For the subjects participating in the first part of the study additional exclusion criteria are (relative) contraindications for the use of intravenous injection of butylscopolamine. For the subjects participating in the second part of the study additional exclusion criteria are contraindications for the use of Nutridrink Juice style Apple (the motility modifying substance).
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>This pilot study is to assess whether these 3D dynamic MRI acquisition and<br /><br>post-processing techniques can be used as a tool to detect and quantify small<br /><br>bowel motility. The main outcome parameter is detection of small bowel<br /><br>motility. </p><br>
- Secondary Outcome Measures
Name Time Method <p>Secondary outcome parameter is the validation and comparison of the two methods<br /><br>by demonstrating the effects of motility modification.</p><br>