Study of Effect of Vitamin D supplementation in Human Immunodeficiency Virus infected children

This is a Non - Randomized active controlled trial to study the effect of supplementation of Vitamin D in HIV ( human immunodeficiency virus)  infected children on Highly Active Anti-Retroviral Treatment. Vitamin D levels were done in 51 HIV patients at enrolment .Patients ere divided in 4 groups by US endocrine Society Classification for Vitamin D levels...GROUP1-  HIV patients with vitamin D deficiency,  GROUP 2- HIV patients with insufficient Vitamin D levels, GROUP 3 - HIV  infected patients with vitamin D sufficient levels , GROUP 4- HIV infected patients with vitamin D toxicity. GROUP 1 & 2 Patients  were supplemented with Vitamin D   2,40,000 IU oral cholecalciferol sachets on day 1 followed by vitamin D3 drops 0.5ml (400 IU)  daily for 12 weeks (1ml = 800 IU) and vitamin D levels were repeated after 4 months. GROUP 3 & 4 placebo ( tab folic acid was given for 12 weeks. Primary Outcomes will be CD4  counts of both groups 1 and 2 will be compared .Secondary outcomes will be 1) Incidence of opportunistic infections in both group 1 and 2.... 2) comparison of CD4 count after vitamin D supplementation in Vitamin D deficient HIV infected children. At final evaluation,the above trial concluded that , CD4 count increased in Group 1,2 and 3 , there was no significant difference in mean CD4 count at all periods among the 3 groups. Similarly, opportunistic infections decrease in group 1,2 and 3 but the mean number of opportunistic infections between the groups at all periods did not differ significantly.