The Incidence of Postoperative Pulmonary Complications in Patients With a Positive and Negative AIR-Test During General Anesthesia
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 632
- 试验地点
- 1
- 主要终点
- The incidence of postoperative pulmonary complications
研究概览
简要总结
The overall objective of this study is to describe the incidence of postoperative pulmonary complications in patients with a positive and negative AIR-test result. Second, the investigators wish to describe the incidence of a positive AIR-test and its association with the development of PPC. In addition, the investigators aim to describe whether mechanical ventilation strategy differs between patients with a positive and negative AIR-test.
详细描述
The 'AIR-test', a method wherein inspiratory oxygen concentration is reduced to 21% and pulse-oximetry hemoglobin saturation (SpO2) is monitored, can be used to demonstrate the presence of an atelectasis-induced alveolar shunt. It remains uncertain whether an intraoperative positive AIR-test is associated with clinical outcomes. It is hypothesized that in a general surgical population, the incidence of postoperative pulmonary complications (PPC) is higher in patients with a positive AIR-test than in patients with a negative AIR-test. The aim of this study is to describe the incidence of PPC in patients with a positive and in patients with a negative AIR-test. Second, the investigators want to describe the incidence of a positive AIR-test and its association with the development of PPC. The investigators also want to evaluate whether mechanical ventilation strategy differs between patients with a positive and negative AIR-test.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 110 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients undergoing surgery under general anesthesia in the Amsterdam University Medical Centers, location Meibergdreef with an Endotracheal Tube;
- •Patients > 18 years;
- •Preoperative SpO2 of ≥97%;
- •AIR-test performed after induction of anesthesia, in a hemodynamic and respiratory steady state.
排除标准
- •Age < 18 years;
- •No consent/objection;
- •Patient participated in another conflicting interventional study on mechanical ventilation during general anesthesia
结局指标
主要结局
The incidence of postoperative pulmonary complications
时间窗: The first 5 postoperative days
Respiratory failure; Bronchospasm; Acute Respiratory Distress Syndrome (ARDS); Suspected pulmonary infection; Aspiration pneumonitis; Atelectasis; Pleural effusion; Pulmonary infiltrate; Cardiopulmonary effusion; Pneumothorax
次要结局
- AIR-test result(Intraoperative period)
- Tidal volume during general anesthesia for surgery(Intraoperative period)
- Peak Pressure during general anesthesia for surgery(Intraoperative period)
- Respiratory Rate during general anesthesia for surgery(Intraoperative period)
- Fraction of Inspired Oxygen during general anesthesia for surgery(Intraoperative period)
- Positive End-Expiratory Pressure during general anesthesia for surgery(Intraoperative period)
- Driving Pressure during general anesthesia for surgery(Intraoperative period)
- The incidence of the individual components of postoperative pulmonary complications(The first 5 postoperative days)
- Length of hospital stay(From the day of surgery until the day of discharge, up to day 30)
- Rate of all-cause mortality and in-hospital mortality(Postoperative day 5 and postoperative day 30)
- End-tidal Carbon Dioxide (CO2) during general anesthesia for surgery(Intraoperative period)
研究者
Prof. Dr. Marcus J. Schultz
Prof. Dr.
Amsterdam UMC, location AMC