The Incidence of Postoperative Pulmonary Complications in Patients With a Positive and Negative AIR-Test During General Anesthesia
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Surgery--Complications
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
- Enrollment
- 632
- Locations
- 1
- Primary Endpoint
- The incidence of postoperative pulmonary complications
- Status
- Completed
- Last Updated
- last year
Overview
Brief Summary
The overall objective of this study is to describe the incidence of postoperative pulmonary complications in patients with a positive and negative AIR-test result. Second, the investigators wish to describe the incidence of a positive AIR-test and its association with the development of PPC. In addition, the investigators aim to describe whether mechanical ventilation strategy differs between patients with a positive and negative AIR-test.
Detailed Description
The 'AIR-test', a method wherein inspiratory oxygen concentration is reduced to 21% and pulse-oximetry hemoglobin saturation (SpO2) is monitored, can be used to demonstrate the presence of an atelectasis-induced alveolar shunt. It remains uncertain whether an intraoperative positive AIR-test is associated with clinical outcomes. It is hypothesized that in a general surgical population, the incidence of postoperative pulmonary complications (PPC) is higher in patients with a positive AIR-test than in patients with a negative AIR-test. The aim of this study is to describe the incidence of PPC in patients with a positive and in patients with a negative AIR-test. Second, the investigators want to describe the incidence of a positive AIR-test and its association with the development of PPC. The investigators also want to evaluate whether mechanical ventilation strategy differs between patients with a positive and negative AIR-test.
Investigators
Prof. Dr. Marcus J. Schultz
Prof. Dr.
Amsterdam UMC, location AMC
Eligibility Criteria
Inclusion Criteria
- •Patients undergoing surgery under general anesthesia in the Amsterdam University Medical Centers, location Meibergdreef with an Endotracheal Tube;
- •Patients \> 18 years;
- •Preoperative SpO2 of ≥97%;
- •AIR-test performed after induction of anesthesia, in a hemodynamic and respiratory steady state.
Exclusion Criteria
- •Age \< 18 years;
- •No consent/objection;
- •Patient participated in another conflicting interventional study on mechanical ventilation during general anesthesia
Outcomes
Primary Outcomes
The incidence of postoperative pulmonary complications
Time Frame: The first 5 postoperative days
Respiratory failure; Bronchospasm; Acute Respiratory Distress Syndrome (ARDS); Suspected pulmonary infection; Aspiration pneumonitis; Atelectasis; Pleural effusion; Pulmonary infiltrate; Cardiopulmonary effusion; Pneumothorax
Secondary Outcomes
- AIR-test result(Intraoperative period)
- Tidal volume during general anesthesia for surgery(Intraoperative period)
- Peak Pressure during general anesthesia for surgery(Intraoperative period)
- Respiratory Rate during general anesthesia for surgery(Intraoperative period)
- Fraction of Inspired Oxygen during general anesthesia for surgery(Intraoperative period)
- Positive End-Expiratory Pressure during general anesthesia for surgery(Intraoperative period)
- Driving Pressure during general anesthesia for surgery(Intraoperative period)
- The incidence of the individual components of postoperative pulmonary complications(The first 5 postoperative days)
- Length of hospital stay(From the day of surgery until the day of discharge, up to day 30)
- Rate of all-cause mortality and in-hospital mortality(Postoperative day 5 and postoperative day 30)
- End-tidal Carbon Dioxide (CO2) during general anesthesia for surgery(Intraoperative period)