Effect of Modified Poco-Poco Exercise to Aging Biomarkers in Elderly

Not Applicable

Recruiting

• Conditions: Geriatrics Rehabilitation

• Registration Number: NCT07042464
• Lead Sponsor: Universitas Padjadjaran

Brief Summary

Subject with sarcopenia get modified poco-poco exercise program for 12 weeks

Detailed Description

34 participants (\>60 years) with sarcopenia were modified poco-poco exercises three times weekly for 12 weeks will assessed sarcopenia staging (determined by assessing skeletal muscle index, muscle strength, physical performance) and levels of global DNA methylation and GDF-15.

Study Timeline

• Study First Submitted: 2025-06-11
• Study First Submitted QC: 2025-06-19
• Study Start: 2025-06-20
• Study First Posted: 2025-06-29
• Status Verified: 2025-07
• Last Update Submitted: 2025-07-01
• Last Update Posted: 2025-07-04
• Primary Completion: 2025-09
• Study Completion: 2025-09-01

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 34

Inclusion Criteria

• Age above 60 years old
• Have sarcopenia (based on AWGSOP 2019 criteria)

Exclusion Criteria

• Hearing impairment/loss hindering participants to receive verbal instructions
• Vision impairment/loss hindering participants to receive instructions
• Musculoskeletal impairment or severe joint diseases (i.e. deformity in Osteoarthritis or Rheumatoid Arthritis)
• Participants have been involved in other exercise program
• Severe cardiovascular disease diagnosed by Cardiologist.
• Participants will be excluded from the research if they skip 3 sessions of the program consecutively or skip 5 sessions cumulatively

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
Sarcopenia Staging (Skeletal Muscle Index)	12 weeks	Skeletal muscle index
Sarcopenia Staging (Muscle Strength)	12 weeks	Hand Grip Strength, score in kilograms
Sarcopenia Staging (Physical Performance)	12 weeks	Short Physical Performance Battery, score in numerical 0-12
Levels of Global DNA Methylation	12 weeks	Global DNA methylation levels were analyzed using the ELISA-based kit
Levels of Growth Differentiation Factor 15	12 weeks	Growth Differentiation Factor 15 were analyzed the Quantikine ELISA Human GDF-15 Immunoassay

Trial Locations

Locations (1)

Hasan Sadikin General Hospital; 🇮🇩 Bandung, Indonesia