Periodontal Disease, Inflammation, Nutritional Status And Anaemia Response To Erythropoietin In Chronic Haemodialyzed Patients - The Impact Of Treatment For Periodontal Disease
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Periodontal Disease
- Sponsor
- Anemia Working Group Romania
- Enrollment
- 30
- Locations
- 1
- Primary Endpoint
- Modification of nutritional status
- Last Updated
- 6 years ago
Overview
Brief Summary
Several studies revealed a direct relationship between the severity of periodontal inflammation and CRP (NHANES III, Dumitriu HT et al, 1998). In patients without any other source of inflammation but PDD, proper dental treatment of the disease decreased CRP to normal levels (Dumitriu H.T. et al., 1998; D'Aiuto F. et al, 2004; Borawski J. et al., 2007) Moreover, a direct link between high levels of CRP and atherosclerotic complications has been found in studies conducted both in general population (Ridker PM, et al., 1998; Koenig W, et al., 1999) and in HD subjects (Westhuyzen J, et al., 2000; Iseki K., et al., 1999; Zimmermann J, et al. 1998).
Detailed Description
Patients will be recruited according to eligibility criteria. Initial oral and general status will be evaluated and recorded. The evaluated parameters are listed at the study description section. Also, quality of life will be assessed by using the SF-36 and OHIP-14 questionnaires. Patients will undergo a series of dental interventions with the final scope of eliminating all oral inflammation. Participants will also be instructed regarding correct oral hygiene habits. Following dental and periodontal treatments, the oral and general status will be reassessed and the obtained dat analysed.
Investigators
Oana Slusanschi
DMD
Anemia Working Group Romania
Eligibility Criteria
Inclusion Criteria
- •Hemodialyzed patients with periodontal disease
Exclusion Criteria
- •Malignancies, Diabetes
- •Patient refusal to participate
Outcomes
Primary Outcomes
Modification of nutritional status
Time Frame: 6 months
SGA, whole body bioimpedance, biochemical parameters (serum albumin, predialysis serum urea, serum creatinine, serum phosphates)
Secondary Outcomes
- Modification of inflammatory status(6 months)