NCT07455175尚未招募不适用
Observational Clinical Study on the Association Between Lactate-mediated Gut Microbiota Alterations and Disease Progression in Liver Cirrhosis.
Zhujiang Hospital1 个研究点 分布在 1 个国家目标入组 200 人开始时间: 2026年4月1日最近更新:
适应症
干预措施
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- Gut microbiota composition
研究概览
简要总结
To investigate the association between lactate-mediated alterations in the gut microbiota and disease progression in patients with liver cirrhosis; and to examine the correlations of lactate levels among serum, fecal, and tissue samples in patients with liver cirrhosis.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy individuals without a history of liver disease or related underlying disorders; or patients diagnosed with liver cirrhosis and its complications based on imaging and/or liver biopsy, with a history of chronic liver disease for more than 6 months. Etiologies include chronic hepatitis B virus infection, nonalcoholic fatty liver disease, and alcoholic liver disease, among others.
- •2. Willing to participate in this study and able to provide written informed consent.
排除标准
- •1. A history of severe organic diseases involving the liver, gastrointestinal tract, kidneys, or other organ systems; malignant tumors; or autoimmune diseases.
- •2. Patients with acute infection or inflammatory diseases within the past 1 month.
- •3. Pregnant or breastfeeding women.
研究组 & 干预措施
Cirrhosis
干预措施: observational study, no intervention (Other)
Healthy control
干预措施: observational study, no intervention (Other)
结局指标
主要结局
Gut microbiota composition
时间窗: baseline
Lactate level
时间窗: baseline
次要结局
未报告次要终点
研究者
研究点 (1)
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