A randomised study on use of impedance cardiography for optimisation of cardiac resynchronisation therapy

Not Applicable

Completed

• Conditions: Heart failure; Circulatory System

• Registration Number: ISRCTN12205645
• Lead Sponsor: Good Hope Hospital NHS Trust (UK)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2006-09-27
• Last Update Posted: 17 October 2016

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

80 patients who are referred to the cardiology clinic and meet the National Institute for Clinical Excellence (NICE) criteria for biventricular pacemaker implantation will be included in this study. The following inclusion criteria are:
1. Heart Failure
2. Moderate to severe function limitation New York Heart Association (NYHA) class III or IV, or NYHA class II heart failure plus a history of repeated admissions
3. Optimal tolerated treatment with diuretics, angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers, beta blockers, spironolactone and digoxin
4. QRS duration (representing the duration of ventricular depolarisation) more than or equal to 120 ms or evidence of mechanical Left Ventricular (LV) dyssynchrony
5. Left ventricular ejection fraction more than or equal to 40%

Exclusion Criteria

1. Contraindications to cardiac pacing
2. Presence of comorbidities likely to threaten survival within 12 months
3. Pulmonary oedema requiring intravenous diuretics in the previous week

Study & Design

• Study Type: Interventional
• Study Design: Not specified