Cerebral Excitability and Cognitive Performance

Not Applicable

• Conditions: Cognitive Change
• Interventions: Other: Stimulation via Soterix Medical or Neuroelectrics noninvasive brain stimulation systems

• Registration Number: NCT03807934
• Lead Sponsor: Tufts University

Brief Summary

This study investigates the perceptual and cognitive influences of low-intensity electrical brain stimulation (transcranial direct current stimulation; tDCS), versus control (sham) conditions.

Detailed Description

Not available

Study Timeline

• Study Start: 2013-04-15
• Study First Submitted: 2019-01-11
• Study First Submitted QC: 2019-01-14
• Study First Posted: 2019-01-17
• Status Verified: 2021-04
• Last Update Submitted: 2021-04-02
• Last Update Posted: 2021-04-05
• Primary Completion: 2023-04-14
• Study Completion: 2023-04-14

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 1500

Inclusion Criteria

• Between ages of 18-65.

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Exclusion Criteria

• History of adverse reaction to tDCS (trans-cranial direct current stimulation).
• History of seizure activity.
• History of head injury (including neurosurgery).
• History of illness causing brain injury.
• History of other brain-related condition (such as traumatic brain injury).
• History of diagnosis with a neurological or psychiatric disorder.
• History of metal in head (outside of mouth), such as shrapnel, surgical clips, or fragments from welding or metalwork.
• History of sensitive scalp.

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Active High-Definition Stimulation	Stimulation via Soterix Medical or Neuroelectrics noninvasive brain stimulation systems	Active high-definition stimulation of targeted brain regions involved in perception and cognition.
Sham High-Definition Stimulation	Stimulation via Soterix Medical or Neuroelectrics noninvasive brain stimulation systems	Sham high-definition stimulation of targeted brain regions involved in perception and cognition.

Primary Outcome Measures

Name	Time	Method
Visual perceptual performance	36 weeks	Ability to accurately and efficiently perceive perceptual information, including threat detection, local contrast gradient detection, face memory, and intent appraisal. All are computerized tasks.
Verbal cognitive performance	36 weeks	Ability to accurately and efficiently process verbal information, including verbal cued free association tasks, verbal long-term memory, and language comprehension. All are computerized tasks.
Spatial cognitive performance	72 weeks	Ability to accurately and efficiently process spatial information, including map learning, virtual urban navigation, and mental rotation. All are computerized tasks.

Trial Locations

Locations (1)

Tufts University; 🇺🇸 Boston, Massachusetts, United States