Incidence of Postoperative Orthostatic Intolerance and Postoperative Orthostatic Hypotension in Patients Undergoing Unilateral Total Knee Arthroplasty
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- Incidence of orthostatic hypotension
研究概览
简要总结
Incidence of Postoperative Orthostatic Intolerance and Postoperative Orthostatic Hypotension in Patients Undergoing Unilateral Total Knee Arthroplasty
详细描述
Early postoperative mobilization is a cornerstone in the so-called fast track multimodal perioperative approach and is essential in preventing postoperative morbidity and reducing hospital length-of-stay. Intact orthostatic blood pressure regulation is essential for early postoperative mobilization. However, early postoperative mobilization can be delayed due to postoperative orthostatic hypotension (POH) defined as a fall in systolic pressure > 20 mmHg and/or diastolic pressure > 10 mmHg or due to postoperative orthostatic intolerance (POI), characterized by dizziness, nausea, vomiting, blurred vision or syncope during mobilization.
Previous prospective studies of major surgery have reported that OI and OH are common problem during early postoperative mobilization, with a prevalence of 42-50%. Retrospective studies with a less-defined mobilization protocols have reported am OI prevalence in the range of 12-60 % across surgical procedures.
The aim of our study is to determine the incidence of OI during early postoperative mobilization in fast track unilateral total knee arthroplasty.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 100 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Written informed consent
- •Patients that speak and understand Danish
- •Patients undergoing primary unilateral total knee arthroplasty in spinal anesthesia and standardized fast-track setting
排除标准
- •Alcohol or drug abuse
- •Cognitive dysfunction
- •Known orthostatic hypotension
- •Use of anxiolytic drugs
结局指标
主要结局
Incidence of orthostatic hypotension
时间窗: 6 hours postoperatively
Orthostatic hypotension is defined as a fall in systolic pressure \> 20 mmHg and/or diastolic pressure \> 10 mmHg during mobilization
Incidence of orthostatic intolerance
时间窗: 6 hours postoperatively
Symptoms of orthostatic intolerance: dizziness, nausea, vomiting, blurry vision or syncope during mobilization
次要结局
- Changes in mean arterial pressure (MAP) during mobilization(Preoperatively, 6 and 24 hours postoperatively)
- Changes in diastolic arterial pressure (DAP) during mobilization(Preoperatively, 6 and 24 hours postoperatively)
- Changes in cardiac output (CO) during mobilization(Preoperatively, 6 and 24 hours postoperatively)
- Changes in systemic vascular resistance (SVR) during mobilization(Preoperatively, 6 and 24 hours postoperatively)
- Changes in stroke volume (SV) during mobilization(Preoperatively, 6 and 24 hours postoperatively)
- Changes in systolic arterial pressure (SAP) during mobilization(Preoperatively, 6 and 24 hours postoperatively)
研究者
Ana-Marija Hristovska
Principal Investigator, Medical Doctor
Hvidovre University Hospital