DRKS00009637已完成未知
The neurochemical basis of individual pain sensitivity and pain modulation, Part II, Study 1 - Neurochem2
niversitätsklinikum Essen, Klinik für Neurologie0 个研究点目标入组 70 人开始时间: 2015年11月26日最近更新:
适应症
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 发起方
- 入组人数
- 70
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized controlled study
- 盲法
- Blinded (masking used)
入排标准
- 年龄范围
- 18 Years 至 40 Years（—）
- 性别
- All
入选标准
- •Age 18 to 40 years.
- •for women: hormonal contraception.
- •Written informed consent.
排除标准
- •Signs of renal, cardiovascular, or hepatic disease.
- •Signs of raised intraocular pressure.
- •Protein-rich diet before study-visit one.
- •History of, or present neurologic disorders, e.g. pain disorders, migraine, lower back pain, irritable bowel syndrome, cranial trauma, epilepsia, or sleep disorder.
- •History of, or present psychiatric disorder, e.g. depression, schizophrenia, substance abuse, or personality disorders.
- •History of, or present severe internal disorders, such as diabetes, neoplasia, thyroid dysfunction, asthma.
- •Acute infections (common cold, diarrhea).
- •Alcohol consumtion at the day of or the day before study participation.
- •Known allergy against any constituent of the study medication.
- •Surgery requiring narcosis within the last 6 months.
- •Participation in any study requiring the intake of study medication within the last 6 months.
- •Any long-term medication, except dietary supplements and hormonal contraception.
- •Intake of pain medication (e.g. NSAIDs) within the last 14 days.
- •For women: Pregnancy.
- •Disorders of the skin that could affect temperature sensation (e.g. neurodermitis).
- •Abnormal pain- or temperature sensitivity at the forearm, defined as :
- •o Heat pain threshold > 50°C.
- •o Warmth detection threshold >37°C.
- •o Unstable heat pain ratings Unzuverlässige Differenzierung von Hitzereizen or VAS40<44.0°C oder VAS80>48.5°C.
研究者
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