Role of lactulose for prophylaxis of hepatic encephalopathy in cirrhotic patients presenting with upper gastrointestinal bleeding
Phase 4
Completed
- Conditions
- Gastrointestinal hemorrhage is a precipitating cause of hepatic encephalopathy in cirrhosis patients. Lactulose is frist line theraphy of hepatic encephalopathy. Can lactulose prevent hepatic encephalhepatic encephalopathylactulosecirrhosisupper gastrointestinal bleedingpreventionprophylaxis
- Registration Number
- TCTR20200526003
- Lead Sponsor
- one
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 48
Inclusion Criteria
cirrhotic patients presenting with upper gastrointestinal bleeding who underwent esophagograstroduodenoscopy within 24 hours after symptom presentation.
Exclusion Criteria
1. underlying disease of neurological disease
2. presence of hepatic encephalopathy at the time of admission
3. history of lactulose usage within 6 weeks before
4. severe co-morbidity such as acute kidney injury, active cardiopulmonary disease
5. history of alcohol ingestion within 7 days before
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Incidence of hepatic encephalopathy day 5 incidence of hepatic encepalopathy according to west haven criteria grade 3 or more
- Secondary Outcome Measures
Name Time Method ength of hospitalization form admission to discharge days