NCT02049424TerminatedNot Applicable
Retrospective-prospective Observational Study for Data Collection of Patients Who Underwent an Haploidentical Transplantation After Non-myeloablative Conditioning Regimen
Istituto Clinico Humanitas1 site in 1 country9 target enrollmentStarted: March 2011Last updated:
Conditions
Trial Snapshot
- Phase
- Not Applicable
- Status
- Terminated
- Sponsor
- Enrollment
- 9
- Locations
- 1
- Primary Endpoint
- toxicity evaluation
Study Overview
Brief Summary
Outcome evaluation in patients who underwent transplantation with T-repleted bone marrow after post-transplantation cyclophosphamide
Detailed Description
Patients who underwent transplantation with T-repleted bone marrow haploidentical transplantation will be analyzed considering toxicity incidence (GVHD, infective complications, graft-failure incidence and TRM)and efficacy variables (Overall Survival, Progression Free Survival and Relapse incidence)
Study Design
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Retrospective
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •patients affected by hematologic neoplasia who underwent a haploidentical transplantation (2-3 mismatches) from a familiar donor, with non-ex vivo manipulated bone marrow and post-transplantation cyclophosphamide
Exclusion Criteria
- •ex vivo manipulated bone marrow transplantation
- •use of antilymphocyte serum during conditioning
Outcomes
Primary Outcomes
toxicity evaluation
Time Frame: 1 year
Chronic and acute GVHD, infectious complications, graft failure, TRM
Secondary Outcomes
No secondary outcomes reported
Investigators
Study Sites (1)
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