Prosthesis Infection and One-step Exchange: Pretreatment by Targeted Antibiotic Therapy in
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Prosthetic Joint Infection
- Sponsor
- Hospices Civils de Lyon
- Enrollment
- 13
- Locations
- 1
- Primary Endpoint
- Rate of Treatment Failure
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
One-step exchange arthroplasty is more and more used in the treatment of chronic infections, especially in patients at risk anesthetic.
This strategy is not recommended in patients infected with multidrug-resistant organisms or difficult to treat because of a risk of bacterial persistence on the new implant.
Antibiotic pretreatment by a narrow-spectrum molecule and for which resistance acquisition is difficult might be of interest to try to reduce the inoculum and avoid contamination of the new implant.
Investigators
Eugénie MABRUT
CRA
Hospices Civils de Lyon
Eligibility Criteria
Inclusion Criteria
- •patients having had a antibiotic pretreatment targeted before a one step exchange arthroplasty
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Rate of Treatment Failure
Time Frame: Outcome is measured at the end of follow-up (usually between 12 and 24 months after antibiotic therapy disruption
Treatment failure is defined by local clinical and/or microbiological relapse; and/or need for additional surgery; death of septic origin
Secondary Outcomes
- rate of bacteria responsible for infection(Outcome is measured at the end of follow-up (usually between 12 and 24 months after antibiotic therapy disruption)
- rate of use of this strategy(Outcome is measured at the end of follow-up (usually between 12 and 24 months after antibiotic therapy disruption)