Does the anti-sickness drug dexamethasone influence immune function in breast surgery?
Phase 4
Completed
- Conditions
- Immune functionAnaesthesiology - AnaestheticsInflammatory and Immune System - Normal development and function of the immune system
- Registration Number
- ACTRN12609000463279
- Lead Sponsor
- Clinical A/Professor Tomas Corcoran
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Female
- Target Recruitment
- 51
Inclusion Criteria
Females undergoing breast surgery
American Society of Anesthesiologists (ASA) Class I-III
Exclusion Criteria
Current drug therapy with antiemetics, steroids or serotonergic antidepressants
Active infection
Known or suspected metastatic disease
Previous chemotherapy treatment
Patients receiving implants, such as mesh repairs
Allergy/intolerance to any of the study drugs (including renal or hepatic impairment, active peptic ulcer disease, ischaemic heart disease, QT prolongation, major psychiatric illness)
Diabetes mellitus or history of seizures
Participation in any other research trial
Pregnant or possibility of
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Proportions of lymphocyte subpopulations on blood analysis[Baseline, 24 hours one week and six weeks after administration of drug]
- Secondary Outcome Measures
Name Time Method Serum Macrophage Inhibitory Factor concentrations[Baseline, 24 hours and 168 hours after administration of drug]