Plasma Adiponectin Level and Sleep Structures in Children With Prader-Willi Syndrome

Completed

• Conditions: Prader-Willi Syndrome; Obesity

• Registration Number: NCT01622751
• Lead Sponsor: Samsung Medical Center

Brief Summary

Context: Adiponectin is an adipose tissue-derived hormone with an insulin sensitizing effect, and has been related to obstructive sleep apnea syndrome. In addition, children with Prader-Willi syndrome (PWS) suffer from excessive daytime sleepiness and the abnormality of rapid eye movement (REM) sleep.

Objective: To determine if the sleep stages are related to the plasma levels of adiponectin, resistin, and RBP4 (retinol binding protein-4), and whether these relationships are influenced by age, obesity and insulin resistance.

Detailed Description

This comparative study was carried out in 28 PWS children and 18 controls. The enrolled PWS children were volunteers out of a pool of approximately 100 PWS children followed at Samsung Medical Center \[median age 8.0 years, interquartile range (7.0-10.5 years), BMI: median 24.2 kg/m2 (23.0-27.5 kg/m2)\] and 18 obese healthy children \[median age 9.0 years interquartile range (7.0-11.0 years), BMI: median 24.2 kg/m2 interquartile range (23.1-27.6 kg/m2)\].

Basic Information
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Recruitment & Eligibility
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Study & Design

Study Timeline

• Study Start: 2007-01
• Study Completion: 2007-06
• Study First Submitted: 2012-01-18
• Status Verified: 2012-06
• Study First Submitted QC: 2012-06-14
• Last Update Submitted: 2012-06-14
• Study First Posted: 2012-06-19
• Last Update Posted: 2012-06-19

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 46

Inclusion Criteria

• Prader Willi syndrome healthy children

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Exclusion Criteria

• history of seizure,
• mental or brain illness,
• adenoidectomy,
• tonsillectomy,
• craniofacial anomalies and any treatment at the time of the study.

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified