Combined tDCS and TMS on Subjective Tinnitus and Combined Depression

Not Applicable

Completed

• Conditions: Tinnitus; Depression
• Interventions: Device: transcranial direct current stimulation (tDCS) and transcranial magnetic stimulation (TMS)

• Registration Number: NCT04262050
• Lead Sponsor: Seoul National University Hospital

Brief Summary

The investigators combined transcranial direct current stimulation (tDCS) and transcranial magnetic stimulation (TMS) to increase the effective response of a single session of neuromodulation in subjective tinnitus.

Detailed Description

To treat motor and psychiatric disorders, transcranial direct current stimulation (tDCS) and transcranial magnetic stimulation (TMS) are world-widely in use in clinics. The investigators combined these two types of neuromodulation techniques to increase the effective response of a single session of neuromodulation in subjective tinnitus. Experimental groups with 80 tinnitus subjects consisted of four different treatment groups which are tDCS, tDCS with sham TMS, tDCS-TMS and TMS group. Subjects were given 1.5milliampere (mA) tDCS on the bi-frontal area and TMS stimulated contralateral single side of the temporoparietal cortex with 200 pulses at 1herz (Hz) stimulation.

Study Timeline

• Study Start: 2016-08-01
• Primary Completion: 2018-07-01
• Study Completion: 2018-07-01
• Status Verified: 2020-02
• Study First Submitted: 2020-02-06
• Study First Submitted QC: 2020-02-07
• Last Update Submitted: 2020-02-07
• Study First Posted: 2020-02-10
• Last Update Posted: 2020-02-10

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

• Research volunteers who agreed to participate in the clinical trial were gathered from the tinnitus clinic of the Department of Otorhinolaryngology Head-and-Neck Surgery, Seoul National University Bundang Hospital

Exclusion Criteria

• psychoactive drug user
• implanted material
• pacemaker user

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
TMS + tDCS group	transcranial direct current stimulation (tDCS) and transcranial magnetic stimulation (TMS)	-
tDCS group	transcranial direct current stimulation (tDCS) and transcranial magnetic stimulation (TMS)	-
sham TMS + tDCS group	transcranial direct current stimulation (tDCS) and transcranial magnetic stimulation (TMS)	-
TMS group	transcranial direct current stimulation (tDCS) and transcranial magnetic stimulation (TMS)	-

Primary Outcome Measures

Name	Time	Method
Tinnitus handicap inventory	the same 1 day after treatment	tinnitus-related questionnaire