Comparative efficacy of Therapeutic Ultrasound versus Phonophoresis with Permeation-Enhanced Diclofenac-Tizanidine Gel in Myofascial Pain Dysfunction Syndrome:A Randomized Controlled Clinical Study

Background: Myofascial Pain Dysfunction Syndrome (MPDS) is a common musculoskeletal condition characterized by muscle pain, trigger points, and functional limitation. Physical therapy modalities such as therapeutic ultrasound and phonophoresis are widely used to relieve pain and inflammation. However, evidence comparing their relative efficacy, especially with permeation-enhanced diclofenac–tizanidine gel, remains limited, warranting comparative clinical evaluation.

Aims: To compare the efficacy of therapeutic ultrasound versus phonophoresis with permeation-enhanced diclofenac–tizanidine gel in reducing pain and improving function in patients with Myofascial Pain Dysfunction Syndrome.

Methodology: A randomized parallel-group active-controlled clinical trial was conducted on patients diagnosed with Myofascial Pain Dysfunction Syndrome. Participants were randomly allocated to receive either therapeutic ultrasound or phonophoresis with permeation-enhanced diclofenac–tizanidine gel. Pain intensity and functional outcomes were assessed pre- and post-intervention using standardized clinical scales.