Effect of Dexamethasone and Epinephrine on the Duration of Sciatic Nerve Blocks With Ropivacaine in Ankle and Foot Surgery
试验速览
- 阶段
- 不适用
- 入组人数
- 90
- 试验地点
- 1
- 主要终点
- time to first analgesic request after postanesthetic care unit discharge
研究概览
简要总结
The aim of the present study is to test that adding dexamethasone or epinephrine significantly prolongs the duration of sciatic nerve blocks with ropivacaine and that the magnitude of the effect differs among dexamethasone and epinehrine.
详细描述
In a double-blinded trial utilizing single-injection sciatic nerve block, patients are randomly assigned to one of three groups: control: 0.5% ropivacaine adding normal saline; epinephrine: 0.5% ropivacaine adding epinephrine; dexamethasone: 0.5% ropivacaine adding dexamethasone. We assess time to first analgesic request after post-anaesthesia care unit discharge.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •American Society of Anesthesiologists physical status I and II
- •patients undergoing elective hallux valgus repair
排除标准
- •patients receiving chronic analgesic therapy
- •peripheral neuropathies
- •psychiatric disorders
- •hypersensitivity to amide local anesthetics
- •renal disorders
研究组 & 干预措施
Dexamethasone
Dexamethasone 8 mg is added to 0.5% ropivacaine 20 ml for sciatic nerve block.
干预措施: Dexamethasone (Drug)
epinephrine
Epinephrine 1:200,000 is added to 0.5% ropivacaine 20 ml for sciatic nerve block.
干预措施: Epinephrine (Drug)
结局指标
主要结局
time to first analgesic request after postanesthetic care unit discharge
时间窗: from arrival in postanesthetic care unit to 72 hours after operation
A blinded observer interview patients at arrival in postanesthetic care unit, 6 hour, 24 hour, 48 hour, 72 hour after operation.
次要结局
- time of recovery of motor and sensory functions on the operated foot(from arrival in postanesthetic care unit to 72 hours after operation)
研究者
Sangjin Park
assistant professor
Yeungnam University College of Medicine