Does prilocaine provide a quicker recovery than bupivacaine when used in spinal anaesthesia for cervical stitch surgery?

Not Applicable

• Conditions: Elective cervical cerclage in pregnant women at risk of pre-term loss; Surgery

• Registration Number: ISRCTN14374515
• Lead Sponsor: Guy's and St Thomas' NHS Foundation Trust

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2021-02-08
• Last Update Posted: 9 September 2024
• Study Completion: 2025-08-31

Recruitment & Eligibility

• Status: Ongoing
• Sex: Female
• Target Recruitment: 135

Inclusion Criteria

Healthy (ASA score 1 or 2) women in the second trimester of pregnancy presenting for elective cervical cerclage under spinal anaesthesia

Exclusion Criteria

1. Inability to read or understand the patient information sheet (PIS)
2. Aged <18 years
3. Unable or unwilling to consent to participation
4. Non-elective procedure
5. Serious co-morbidities (ASA score 3 or above)
6. Any contraindication to SAB, e.g. local or generalised infection, active central nervous system disease, coagulation disorders or anti-coagulant medication
7. Any history of allergic reaction to any of the medications in the protocol
8. Concomitant use of class III antiarrhythmics (sulfonamides, antimalarials, sodium nitroprussate, nitroglycerin, other local anaesthetics)
9. Any contraindication to the use of bupivacaine or prilocaine as listed in the SmPCs

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Time taken in minutes from initiation of SAB (time 0) until regression of motor block as assessed using a Bromage score* of I. This will be assessed every 5 minutes in theatre until 20 minutes and then every 15 minutes postoperatively until regression of motor block.