Role of Histamine H1/H2 Receptors in the Health- and Performance-promoting Adaptations to High-intensity Interval Training
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 19
- 试验地点
- 1
- 主要终点
- Change in cardiorespiratory fitness
研究概览
简要总结
Exercise training is beneficial for both health and performance. Histamine has been shown to be involved in the acute exercise response. The current study addresses the role of histamine H1/H2 receptor signaling in the chronic training-induced adaptations. Results from this study will yield more insights into the molecular mechanisms of adaptations to exercise training.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
盲法说明
Double-blind for researchers and participants
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Sedentary or low levels of physical activity
- •Caucasian
排除标准
- •Chronic diseases
- •Medication use
- •Excessive alcohol consumption
- •Seasonal allergies
研究组 & 干预措施
Placebo
6 weeks high-intensity interval training + placebo intake
干预措施: Lactose (Other)
Placebo
6 weeks high-intensity interval training + placebo intake
干预措施: High-intensity interval training (HIIT) (Other)
Blockade
6 weeks high-intensity interval training + histamine H1/H2 receptor blockade
干预措施: Fexofenadine Hydrochloride (Drug)
Blockade
6 weeks high-intensity interval training + histamine H1/H2 receptor blockade
干预措施: Famotidine (Drug)
Blockade
6 weeks high-intensity interval training + histamine H1/H2 receptor blockade
干预措施: High-intensity interval training (HIIT) (Other)
结局指标
主要结局
Change in cardiorespiratory fitness
时间窗: Before, after 3 weeks and after 6 weeks of exercise training
Change in maximal oxygen uptake during incremental cycling test on cycle ergometer during the 6 week training period
Change in peak aerobic power output
时间窗: Before, after 3 weeks and after 6 weeks of exercise training
Change in peak power output during incremental cycling test on cycle ergometer during the 6 week training period
Change in whole-body insulin sensitivity
时间窗: Before and after 6 weeks of exercise training
Change from baseline in Matsuda index for whole-body insulin sensitivity derived from Oral Glucose Tolerance Test after the 6 week training period
Change in microvascular function
时间窗: Before and after 6 weeks of exercise training
Change from baseline in microvascular function (Single Passive Leg Movement technique) after the 6 week training period
次要结局
- Change in substrate oxidation during submaximal cycling(Before and after 6 weeks of exercise training)
- Change in blood lactate accumulation during submaximal cycling(Before and after 6 weeks of exercise training)
- Change in fasted serum glucose concentrations(Before and after 6 weeks of exercise training)
- Change in body weight(Before and after 6 weeks of exercise training)
- Change in skeletal muscle protein content(Before and after 6 weeks of exercise training)
- Change in skeletal muscle capillarization(Before and after 6 weeks of exercise training)
- Change in power output at Gas Exchange Threshold (GET)(Before, after 3 weeks and after 6 weeks of exercise training)
- Change in skeletal muscle enzyme activity(Before and after 6 weeks of exercise training)
- Change in power output at Respiratory Compensation Point (RCP)(Before, after 3 weeks and after 6 weeks of exercise training)
- Change in time to exhaustion performance test(Before, after 3 weeks and after 6 weeks of exercise training)
- Change in heart rate during submaximal cycling(Before and after 6 weeks of exercise training)
- Change in cycling efficiency during submaximal cycling(Before and after 6 weeks of exercise training)
- Change in fasted serum insulin concentrations(Before and after 6 weeks of exercise training)
- Change in fasted serum cholesterol concentrations(Before and after 6 weeks of exercise training)
- Change in fasted serum triglyceride concentrations(Before and after 6 weeks of exercise training)
- Change in resting heart rate(Before and after 6 weeks of exercise training)
- Change in resting blood pressure(Before and after 6 weeks of exercise training)