Study of the Laboratory-based Evaluation of the Degrees of Activity of Osteoarthritis
- Conditions
- Osteoarthritis
- Registration Number
- NCT03164070
- Lead Sponsor
- The Republican Research and Practical Center for Epidemiology and Microbiology
- Brief Summary
This study evaluates laboratory-based method to estimate the degrees of activity of medium and large joint osteoarthritis.
- Detailed Description
Osteoarthritis (OA) is a chronic progressive disease, characterized by degradation of joint cartilage, synovial inflammation and joint dysfunction. This study evaluates laboratory-based method to estimate the degrees of activity of medium and large joint OA. Samples of synovial fluid (SF) from the patients with the OA (ICD-10 codes: M15, M16 and M17) will be assessed for T-cell subsets, msast cells, fibroblast-like synoviocytes (FLS) and macrophage-like synoviocytes (MLS) by flow cytometry. Subpopulations of blood T-cells involved in the inflammation will also be assayed. Standard clinical investigation will be performed and the results will be used to estimate the laboratory criteria or degrees of activity of medium and large joint OA.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 121
- medium and large joint active osteoarthritis
- refuse of patient to participate in the trial;
- acute infectious diseases;
- pregnancy/lactation;
- intercurrent severe chronic diseases;
- HIV, Hepatites B/C;
- active tuberculosis;
- alcohol use disorder/drug addiction;
- malignant neoplasms/leukemia.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The sensitivity of the proposed laboratory-based method in the diagnostics of the activity of osteoarthritis 2 month The sensitivity of the proposed laboratory-based method in the diagnostics of the activity of medium and large joint osteoarthritis
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Andrei Hancharou
🇧🇾Minsk, Belarus