Safety and Effectiveness of Laparoscopic Colorectal Resection in Elderly Patients With Colorectal Cancer
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 360
- 试验地点
- 1
- 主要终点
- perioperative complications
研究概览
简要总结
This is a nested cohort study of OAMBP-01. Patients over 70 years old were enrolled into the data-analysis.
The purpose of this study was to examine the feasibility and safety of laparoscopic colorectal resection in elderly patients from a single center, and to explore if there are advantages in laparoscopic surgery.
详细描述
Surgical resection remains the primary treatment for CRC. Despite advancements in surgical techniques, treating elderly cancer patients remains challenging for surgeons. Perioperative risk increases as elderly patients are susceptible to cardiovascular and respiratory diseases. In addition, it has been demonstrated that elderly individuals come with more locally advanced tumor and are more likely to have obstructive or disseminated disease at the time of presentation. In addition, aging diminishes a person's physiological capacity to withstand a major operation. Therefore, surgeons preferred to choose laparotomic colorectal resection to reduce surgical duration and morbidity..
The benefits of laparoscopic colorectal resections over laparotomic surgery have been clearly demonstrated in the general population. However, previous clinical trials comparing surgical approach between laparoscopy and laparotomy restricted the patient's age <75 years, we have limited information on short- and long-term safety and efficacy of elderly patients underwent laparoscopic colorectal resection.
The purpose of this study was to examine the feasibility and safety of laparoscopic colorectal resection in elderly patients from a single center, and to explore if there are advantages in laparoscopic surgery.
This is a nested cohort study of OAMBP-01. Patients over 70 years old were enrolled into the data-analysis.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 70 Years 至 100 Years（Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patient underwent elective laparoscopic or laparotomic colorectal resection for cancer treatment;
- •Patient baseline characteristics and surgical information were available;
- •Patients with complete follow-up data.
排除标准
- •Emergency surgery for causes including bowel obstruction, bleeding, or perforation;
- •Multiple primary malignancies;
- •Failure to follow-up.
结局指标
主要结局
perioperative complications
时间窗: 42 days after surgery
include anastomotic leakage, surgical site infection, postoperative ileus, respiratory/urinary tract infection, and deep vein thrombosis (DVT)
次要结局
- overall survival(5 years)
- disease free survival(5 years)
研究者
Hongbo Wei
Director of Gastrointestinal Surgery department
Third Affiliated Hospital, Sun Yat-Sen University