Laparoscopic Colorectal Resection in Elderly

Completed

• Conditions: Colorectal Cancer
• Interventions: Procedure: laparoscopic surgery

• Registration Number: NCT05563441
• Lead Sponsor: Third Affiliated Hospital, Sun Yat-Sen University

Brief Summary

This is a nested cohort study of OAMBP-01. Patients over 70 years old were enrolled into the data-analysis.

The purpose of this study was to examine the feasibility and safety of laparoscopic colorectal resection in elderly patients from a single center, and to explore if there are advantages in laparoscopic surgery.

Detailed Description

Surgical resection remains the primary treatment for CRC. Despite advancements in surgical techniques, treating elderly cancer patients remains challenging for surgeons. Perioperative risk increases as elderly patients are susceptible to cardiovascular and respiratory diseases. In addition, it has been demonstrated that elderly individuals come with more locally advanced tumor and are more likely to have obstructive or disseminated disease at the time of presentation. In addition, aging diminishes a person's physiological capacity to withstand a major operation. Therefore, surgeons preferred to choose laparotomic colorectal resection to reduce surgical duration and morbidity..

The benefits of laparoscopic colorectal resections over laparotomic surgery have been clearly demonstrated in the general population. However, previous clinical trials comparing surgical approach between laparoscopy and laparotomy restricted the patient's age \<75 years, we have limited information on short- and long-term safety and efficacy of elderly patients underwent laparoscopic colorectal resection.

The purpose of this study was to examine the feasibility and safety of laparoscopic colorectal resection in elderly patients from a single center, and to explore if there are advantages in laparoscopic surgery.

This is a nested cohort study of OAMBP-01. Patients over 70 years old were enrolled into the data-analysis.

Study Timeline

• Study Start: 2015-01-20
• Primary Completion: 2019-12-20
• Study First Submitted: 2022-09-29
• Study First Submitted QC: 2022-09-30
• Study First Posted: 2022-10-03
• Study Completion: 2023-01-31
• Status Verified: 2023-04
• Last Update Submitted: 2023-04-03
• Last Update Posted: 2023-04-05

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 360

Inclusion Criteria

• 1. Patient underwent elective laparoscopic or laparotomic colorectal resection for cancer treatment; 2. Patient baseline characteristics and surgical information were available; 3. Patients with complete follow-up data.

Exclusion Criteria

• 1. Emergency surgery for causes including bowel obstruction, bleeding, or perforation; 2. Multiple primary malignancies; 3. Failure to follow-up.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
laparoscopic surgery	laparoscopic surgery	Patients over 70 years old underwent laparoscopic colorectal resection were enrolled.

Primary Outcome Measures

Name	Time	Method
perioperative complications	42 days after surgery	include anastomotic leakage, surgical site infection, postoperative ileus, respiratory/urinary tract infection, and deep vein thrombosis (DVT)

Secondary Outcome Measures

Name	Time	Method
overall survival	5 years	long term prognosis
disease free survival	5 years	long term prognosis

Trial Locations

Locations (1)

Third Affiliated Hospital of Sun-Yat sen University; 🇨🇳 Guangzhou, Guangdong, China