Comparison of metformin-megestrol combination and megestrol alone on endometrial histology in patients with disordered proliferative or hyperplastic endometrium.
Phase 2
- Conditions
- Patients with abnormal bleeding and endometrial proliferative and Hayprplastyk with irregular glands with and without atypia.Endometrial glandular hyperplasia
- Registration Number
- IRCT201410275283N11
- Lead Sponsor
- Vice chancellor for Research,Tabriz University Of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- Female
- Target Recruitment
- 84
Inclusion Criteria
Patients with abnormal uterine bleeding and havingdisordered proliferative or hyperplastic endometrium with or without atypia; Consent to participate.
Exclusion criteria: Patients who have allergy to metformin; Patients with renal failure; nausea, vomiting, anorexia; anemia; cutaneous lesionsor not satisfied to participate in the study.
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Endometrial pathology. Timepoint: Before surgery. Method of measurement: Pathological evaluation.;Histologic types of endometrial. Timepoint: Three months after the first dose. Method of measurement: Microscopic examination.
- Secondary Outcome Measures
Name Time Method