NCT02093858Unknown不适用
The Mechanism of TCF7L2 and SLC30A8 on Antipsychotic-induced Metabolic Syndrome
Central South University1 个研究点 分布在 1 个国家目标入组 212 人开始时间: 2014年4月最近更新:
适应症
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 212
- 试验地点
- 1
- 主要终点
- Change in weight and blood glucose
研究概览
简要总结
Almost all of antipsychotics can induce metabolic syndrome,Genetic factors play a key role in the development of metabolic syndrome,TCF7L2 and SLC30A8 are strongestly correlated with metabolic syndrome.Moreover,Antipsychotics have an effect on the expression of TCF7L2 and SLC30A8 genes.It indicates the variations of TCF7L2 and SLC30A8 play an important part in the development of antipsychotics-induced metabolic syndrome.
详细描述
- In this study, we will determine the effect of olanzapine on the expression of TCF7L2 and SLC30A8.
- The relationship of the polymorphism of TCF7L2 and SLC30A8 with antipsychotic-induced metabolic syndrome in schizophrenia patients.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Clinical diagnosis of first episode schizophrenia
- •Must be able to swallow tablets
- •Take only one antipsychotics
排除标准
- •liver or renal or cardiovascular diseases
- •pregnant or lactating women
- •drug and alcohol dependence
结局指标
主要结局
Change in weight and blood glucose
时间窗: 24 weeks
次要结局
- Change of the blood pressure and blood lipid(24 weeks)
研究者
Renrong Wu
PhD
Central South University
研究点 (1)
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