Campylobacter Spp. Bone and Joint Infection: a Retrospective Cohort Study

Recruiting

• Conditions: Campylobacter Infections
• Interventions: Other: Management, progression and risk factors for failure of BJI caused by Campylobacter spp.; Other: Description of the evolution and risk factors for failure of osteoarticular infections caused by Campylobacter spp.

• Registration Number: NCT06425250
• Lead Sponsor: Hospices Civils de Lyon

Brief Summary

Campylobacter bacteria, a Gram-negative bacillus commensal in the digestive tract of many animals and mainly responsible for human infections with digestive origins, has been little studied in the field of osteoarticular infections (OAI). Campylobacter spp. are, however, well described, mainly for C. fetus, and pose a dual therapeutic problem: i) a capacity for persistence due to the capacity of most strains to form biofilm; and ii) potential resistance to many antibiotics. The management of IOA caused by Campylobacter spp. is not codified, and is based on small series of cases reported in the literature.

Detailed Description

Not available

Study Timeline

• Study Start: 2024-01-01
• Primary Completion: 2024-04-01
• Status Verified: 2024-05
• Study First Submitted: 2024-05-17
• Study First Submitted QC: 2024-05-17
• Last Update Submitted: 2024-05-17
• Study First Posted: 2024-05-22
• Last Update Posted: 2024-05-22
• Study Completion: 2024-06-30

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

• > 18 years
• Osteoarticular infection (whatever its type), mono or polymicrobial with Campylobacter spp., diagnosed between 01/01/2013 and 12/31/2022:
• Septic arthritis: compatible clinical signs + joint fluid sample positive in culture and/or PCR positive for Campylobacter
• Spondylodiscitis: clinical signs and MRI compatible + blood cultures and/or disco-vertebral biopsy puncture positive in culture and/or PCR positive for Campylobacter
• Osteitis/osteomyelitis: compatible clinico-radiological picture + bone sample (biopsy or intraoperative sample) positive in culture and/or positive PCR for Campylobacter
• Infection on joint prosthesis or osteosynthesis equipment: documented Campylobacter infection and meeting the definition of probable or confirmed JIBS infections
• Patient who was informed and did not object to participating in the study

Exclusion Criteria

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Management, progression and risk factors for failure of BJI caused by Campylobacter spp.	Description of the evolution and risk factors for failure of osteoarticular infections caused by Campylobacter spp.	Adult patients treated for prosthetic joint infection caused by Campylobacter spp. between 01/01/2013 and 12/31/2022
Management, progression and risk factors for failure of BJI caused by Campylobacter spp.	Management, progression and risk factors for failure of BJI caused by Campylobacter spp.	Adult patients treated for prosthetic joint infection caused by Campylobacter spp. between 01/01/2013 and 12/31/2022

Primary Outcome Measures

Name	Time	Method
Outcome of Campylobacter spp. BJI, measured as the proportion of treatment failure.	Outcome will be measure at 1 year. For patients lost of follow-up or followed-up less than a year, the date of last visit will be used for survival curve analysis .	Treatment failure will be defined as: i) infection persistence under appropriate antimicrobial therapy; ii) infection relapse; iii) need for unplaned surgery; iv) superinfection and/or v) infection-related death

Trial Locations

Locations (1)

Service des maladies infectieuses et tropicales - Hôpital de la Croix-Rousse; 🇫🇷 Lyon, France