Effect of Remote Ischemic Postcondioning on Glymphatic System in Acute Stroke

Not Applicable

• Conditions: Stroke
• Interventions: Procedure: remote ischemic postcondioning; Drug: standard therapy

• Registration Number: NCT05305625
• Lead Sponsor: The Affiliated Hospital of Xuzhou Medical University

Brief Summary

Investigators aimed to investigate the changes of glymphatic function after remote ischemic postcondioning treatment in acute ischemic stroke .

Detailed Description

Not available

Study Timeline

• Status Verified: 2022-01
• Study First Submitted: 2022-01-25
• Study First Submitted QC: 2022-03-30
• Last Update Submitted: 2022-03-30
• Study First Posted: 2022-03-31
• Last Update Posted: 2022-03-31
• Study Start: 2022-05-01
• Primary Completion: 2023-05-01
• Study Completion: 2023-05-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• The patient was 18-80 years old;
• The NIHSS score was ≤ 25 and NIHSS > 5，Glasgow coma score ≥ 8;
• The patients were diagnosed as anterior circulation cerebral infarction and could start remote ischemic postcondioning within 24 hours after onset
• Normal to random time within 24 hours
• Written informed consent signed by patients or their families

Exclusion criteria:

• patients receiving thrombolysis or endovascular therapy;
• modified Rankin scale (mRS) score ≥ 2 before this attack;
• other intracranial lesions, such as cerebral hemorrhage, cerebral venous disease, severe subclavian artery stenosis and other diseases involving the brain;
• Arterial blood pressure ≤ 90/60mmHg or ≥ 180/100mmHg after treatment.

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
remote ischemic postcondioning and standard therapy	remote ischemic postcondioning	Patients will be treated with remote ischemic postcondioning and Guideline standard , remote ischemic postcondioning twice a day for a total of 3 days.
standard therapy	standard therapy	Patients will be treated with Guideline standard
remote ischemic postcondioning and standard therapy	standard therapy	Patients will be treated with remote ischemic postcondioning and Guideline standard , remote ischemic postcondioning twice a day for a total of 3 days.

Primary Outcome Measures

Name	Time	Method
Changes of glial lymphatic system	from baseline to 3 day	The size of the vascular spaces was assessed by brain magnetic resonance of ischemic postcondioning group and standard therapy group

Secondary Outcome Measures

Name	Time	Method
Differential expression pattern of differential proteins	from baseline to 3 day	Differential expression pattern of differential proteins in blood of patients with remote ischemic postcondioning group and standard therapy group