The effect of appendectomy on the clinical course of Ulcerative colitis: a randomized multicenter trial

Completed

• Conditions: inflammatory bowel disease; Ulcerative colitis; 10017969

• Registration Number: NL-OMON53054
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 154

Inclusion Criteria

- Aged 18 years and older
- Established diagnosis of ulcerative colitis (any extent of disease)
- Disease relapse within 12 months of randomisation medically treated until
remission
- Clinical (Mayo score <3) and endoscopic (Mayo score 0 or 1) remission
- Obtained written informed consent

Exclusion Criteria

- Prior appendectomy or other major abdominal surgery precluding safe
appendectomy
- Any suspicion of Crohn's disease
- Disease recently treated with biologicals within 3 months prior to inclusion
- Severe disease ever treated with biologicals and stopped due to secondary
non-response
- Toxic megacolon or severe ongoing colitis at time of randomimsation
- Patients with active extra-intestinal infections, liver or kidney failure,
mayor lung and heart co-morbidity.
- Insufficient command of Dutch or cognitively unable to complete Dutch
questionnaires

Study & Design

• Study Type: Interventional
• Study Design: Not specified