NL-OMON40810招募中不适用
Explorations into the cerebral mechanisms of dopa-responsive and dopa-resistant Parkinson*s resting tremor - Dopa-responsive vs. dopa-resistant tremor in PD
niversitair Medisch Centrum Sint Radboud0 个研究点目标入组 105 人开始时间: 待定最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 105
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •- Idiopathic Parkinson*s disease according to UK brain bank criteria.
- •- Presence of a clear resting tremor of at least one arm (UPDRS tremor-score 2 or more).
- •- Dopaminergic therapy with a clear clinical response of non-tremor symptoms (bradykinesia, rigidity).
- •- Milde tot moderate disease severity (Hoehn and Yahr 1-3).
排除标准
- •- Neurological or psychiatric co-morbidity (e.g. stroke, depression).
- •- Severe head tremor or dyskinesias.
- •- Cognitive impairment (MMSE < 26).
- •- General MRI exclusion criteria (e.g. pacemaker, implanted metal parts, deep brain stimulation, claustrophobia).
- •- Co-medication associated with elongated QT-time.
- •- Pregnancy.
- •- Age < 25 years.
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