Effect of Interval Training on Arterial Stiffness in Women With Hypertension

Not Applicable

Completed

• Conditions: Arterial Stiffness
• Interventions: Other: interval training exercise

• Registration Number: NCT04862754
• Lead Sponsor: Cairo University

Brief Summary

this study is aiming to assess the chronic effect of the interval training program on arterial stiffness in women with hypertension

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2021-01-12
• Study Start: 2021-01-25
• Primary Completion: 2021-03-30
• Study Completion: 2021-04-15
• Study First Submitted QC: 2021-04-23
• Study First Posted: 2021-04-28
• Status Verified: 2022-03
• Last Update Submitted: 2022-03-14
• Last Update Posted: 2022-03-15

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 50

Inclusion Criteria

• physically inactive
• BMI 30-40
• Stage 1 and 2 hypertension
• Elevated BP as systolic BP ≥130 mm Hg and/or diastolic BP ≥85 mm Hg measured at the brachial artery.

Exclusion Criteria

• Medications known to affect weight or appetite
• Any disease associated with exercise intolerance.
• Women were taking hormone replacement therapy

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
interval training	interval training exercise	Aerobic interval training. It consisted of a modified interval cycle ergometer training program (3 days a week for 8 weeks). AIT consisted of 8 min warm up, followed by four times of 4-min intervals with HR at 80% of submaximal predetermined HR, with active phases of 3 min of cycling at 60% of submaximal predetermined HR. The exercise session was terminated by 5 min cool down

Primary Outcome Measures

Name	Time	Method
Central arterial stiffness measurements (Pulse Wave Velocity [PWV], augmentation index )	two months	Pulse wave analysis (PWA) of the women in the two groups: pre and post treatment for pulse wave velocity (PWV) and augmentation index(AIx); Pulse Wave Velocity \[PWV\], augmentation index (AIx @75HR) and resting heart rate were measured using analysis equipment which called Non-invasive blood pressure measurement system using "Mobil-O-Graph 24h PWA " with Hypertension Management Software Client Server (HMS-CS 4.3). PWA was performed using an oscillometric Mobil-O-Graph R 24 h PWA Monitor device (I.E.M GmbH, Germany) with integrated ARCSolver® software

Secondary Outcome Measures

Name	Time	Method
blood lipid profile	two months	blood analysis will be used to measure lipid profile (high and low-density lipoprotein, cholesterol, triglyceride)
interleukin 6	two months	blood analysis will be used to measure interleukin 6
blood pressure (systolic and diastolic)	two months	resting Blood pressure was monitored from the right arm using an automated digital electronic BP monitor (Omron digital BP monitor, Model 11 EM 403c; Tokyo Japan).

Trial Locations

Locations (1)

Faculty of physical therapy; 🇪🇬 Cairo, Egypt