Strength Training and Resveratrol

Not Applicable

Not yet recruiting

• Conditions: Sarcopenia; Anabolic Resistance

• Registration Number: NCT06585865
• Lead Sponsor: Texas Tech University

Brief Summary

The main goal of this study is to find out if supplementing with resveratrol improves skeletal muscle adaptations to strengthening exercise (resistance training or strength training) in adults age 60+, and to determine whether circulating vehicles of inter-organ communication (extracellular vesicles) and their cargo might help explain those responses. The investigators will also examine whether resveratrol supplementation improves blood vessel function and cognitive function (brain health) in response to strength training.

Detailed Description

After screening and providing informed consent, participants (healthy older adults, age 60+, minimally active) will be familiarized with the procedures and undergo pre-testing. After pre-testing, participants will be assigned to supplement with resveratrol or placebo (double-blinded) daily while undergoing a strength training intervention. Strength training will be performed 3x/week for two 6-week blocks, and each visit will be supervised by a member of the study team. An additional week of testing will follow each of the two 6-week blocks.

Study Timeline

• Study First Submitted: 2024-09-03
• Study First Submitted QC: 2024-09-03
• Study First Posted: 2024-09-19
• Status Verified: 2024-11
• Last Update Submitted: 2024-11-02
• Last Update Posted: 2024-11-05
• Study Start: 2025-02
• Primary Completion: 2026-04
• Study Completion: 2026-08

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 36

Inclusion Criteria

• Age 60+
• Minimally active (less than 1 hour of structured exercise/week other than walking)
• No resistance training for the previous 6 months
• Not currently taking resveratrol supplements
• Stable medication, supplement, dietary, and physical activity regimens for the previous 3 months and no plans to change throughout the study period

Exclusion Criteria

• Medical complications that could increase risk during exercise (e.g., cardiovascular disease, uncontrolled hypertension, type 1 or 2 diabetes, orthopedic contraindication to exercise, kidney disease, etc.)
• Cannabis or nicotine use
• Consume more than 7 alcohol-containing beverages per week

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Circulating extracellular vesicle microRNA profile	During pre-, mid-, and post-testing (each separated by about 6 weeks)	Circulating extracellular vesicles will be isolated from plasma and their microRNA cargo will be sequenced.
Muscle torque	During pre-, mid-, and post-testing (each separated by about 6 weeks)	Participants will be instructed to try and straighten their leg, against resistance, as forcefully as possible and maximal torque of the quadriceps assessed using a dynamometer.
Muscle fatigability	During pre-, mid-, and post-testing (each separated by about 6 weeks)	Participants will perform 32 repetitions of knee extensions on a dynamometer and the change in torque from the beginning to the end will be used to indicate fatigability.
Muscle strength	During pre-, mid-, and post-testing (each separated by about 6 weeks)	Participants will perform submaximal testing to assess strength on key exercises included in the strength training protocol.
Appendicular skeletal muscle mass index	During pre-, mid-, and post-testing (each separated by about 6 weeks)	Assessed using dual-energy x-ray absorptiometry (DEXA)

Secondary Outcome Measures

Name	Time	Method
Waist-to-hip ratio	During pre-, mid-, and post-testing (each separated by about 6 weeks)	Waist and hip circumferences measured using measuring tape
Vascular function	During pre-, mid-, and post-testing (each separated by about 6 weeks)	Flow-mediated dilation
Cognitive function	During pre-, mid-, and post-testing (each separated by about 6 weeks)	Repeatable Battery for the Assessment of Neuropsychological Status (RBANS)
Grip strength	During pre-, mid-, and post-testing (each separated by about 6 weeks)	Handgrip dynamometry
Lower body strength/endurance	During pre-, mid-, and post-testing (each separated by about 6 weeks)	Chair stand test (30 seconds)
Gait speed	During pre-, mid-, and post-testing (each separated by about 6 weeks)	4-m walk test

Trial Locations

Locations (1)

Department of Kinesiology & Sport Management, Texas Tech University; 🇺🇸 Lubbock, Texas, United States