Pathogen Detection in Infectious Uveitis

• Conditions: Infectious Panuveitis; Infectious Iridocyclitis

• Registration Number: NCT04521673
• Lead Sponsor: Xinhua Hospital, Shanghai Jiao Tong University School of Medicine

Brief Summary

Infectious uveitis is a very important blinding disease. Some people who have been diagnosed with idiopathic uveitis may also have the activity of pathogens in the eye. However, due to the limitation of the amount of ocular samples, it is difficult to make a rapid and effective diagnosis of infection.Current study is to explore the infective cause of uveitis in China by using a broad diagnostic approach of detection.

Detailed Description

Infectious uveitis is a very important blinding disease. Some people who have been diagnosed with idiopathic uveitis may also have the activity of pathogens in the eye. However, due to the limitation of the amount of ocular samples, it is difficult to make a rapid and effective diagnosis of infection.

The study is to explore the infective cause of uveitis in China by using a broad diagnostic approach of detection, including multiple molecular bio-techniques. We also plan to explore the distribution of pathogens in infectious uveitis.

Study Timeline

• Status Verified: 2020-08
• Study First Submitted: 2020-08-19
• Study First Submitted QC: 2020-08-19
• Study First Posted: 2020-08-20
• Last Update Submitted: 2020-08-20
• Last Update Posted: 2020-08-21
• Study Start: 2020-10-01
• Primary Completion: 2022-09-30
• Study Completion: 2022-09-30

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• Patient at a referal hospital eye clinic with clinically suspected infectious uveitis

Exclusion Criteria

• Patients not eligible for the Inclusion Criteria
• Confirmed auto-immune uveitis

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Prevalence and distribution of intraocular infections in the study group	Oct 2020 to Sep 2022	Prevalence and distribution of intraocular infections in the study group

Secondary Outcome Measures

Name	Time	Method
The sensitivity and specificity of multiple molecular diagnostic methods for detection of bacteria or virus fungi in the study group	Oct 2020 to Sep 2022	The sensitivity and specificity of multiple molecular diagnostic methods for detection of bacteria or virus fungi in the study group

Trial Locations

Locations (1)

Xinhua Hospital; 🇨🇳 Shanghai, China