Stress and Oesophageal Acid Perceptio
Completed
- Conditions
- gasto-oesophageal reflux diseaseheartburn10017943
- Registration Number
- NL-OMON32280
- Lead Sponsor
- niversitair Medisch Centrum Utrecht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 25
Inclusion Criteria
Healthy volunteers: no symptoms/history of gastro-oesophageal reflux disease
Patients with gastro-oesophageal reflux disease: previously diagnosed with gastro-oesophageal reflux disease with good association between symptoms and reflux episodes
Exclusion Criteria
Surgery of the gastro-intestinal tract
Psychiatric disorders
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>For both measurements time necessary to provoke first perception, discomfort<br /><br>and pain during the acid perfusion will be assessed. </p><br>
- Secondary Outcome Measures
Name Time Method <p>Systolic and diastolic blood pressure (mmHg) and heart rate (beats/min) will be<br /><br>assessed during both measurements in order to assess the reaction to mental<br /><br>stress task.<br /><br>The State and Trait Anxiety Inventory (STAI)/Zelf Beoordelings Vragenlijst<br /><br>(ZBV) is scored before introducing the manometry and pH catheter on both<br /><br>measurement days.<br /><br>The pH recording will show pH levels in the distal oesophagus during the acid<br /><br>perfusion test continuously. Afterwards, total time with pH<4 will be<br /><br>calculated and presented in minutes. </p><br>