Identification of Volatile Organic Compounds in Exhaled Air During Exacerbation of Chronic Obstructive Pulmonary Disease

Terminated

• Conditions: Chronic Obstructive Pulmonary Disease
• Interventions: Other: Measurement of VOC in exhaled air

• Registration Number: NCT02529891
• Lead Sponsor: Centre Hospitalier Universitaire de Saint Etienne

Brief Summary

Exacerbations of the disease are a hallmark of Chronic Obstructive Pulmonary Disease (COPD), affecting the decline of pulmonary function, quality of life and increasing morbidity. The use of validated biomarkers could help to identify the etiology of exacerbation and to prescribe antibiotherapy when indicated.

The analysis of exhaled air allows measuring different volatile organic compounds (VOC) which reflect local or systemic inflammation and oxidative stress. The relationship between the presence of some of these compounds and the exacerbation of COPD has never been studied.

The aim of this study is to identify a cluster of VOC in COPD patients during an acute exacerbation of the disease, compared to a stable condition (3 months after discharge). Investigators also will seek for a relationship between VOC and the etiology of exacerbation (bacterial, viral, inflammatory).

Detailed Description

Not available

Study Timeline

• Study Start: 2014-08-08
• Study First Submitted: 2015-08-19
• Study First Submitted QC: 2015-08-19
• Study First Posted: 2015-08-20
• Status Verified: 2017-10
• Primary Completion: 2017-10-17
• Study Completion: 2017-10-17
• Last Update Submitted: 2017-10-17
• Last Update Posted: 2017-10-19

Recruitment & Eligibility

• Status: TERMINATED
• Sex: All
• Target Recruitment: 19

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
non-COPD patients	Measurement of VOC in exhaled air	Healthy person of the entourage of COPD patients.
COPD Patients	Measurement of VOC in exhaled air	Patients with COPD, within 48h after hospital admission for exacerbation.

Primary Outcome Measures

Name	Time	Method
Spectrum of VOC measured with a portable mass spectrometer system	Day 1 (within 48 hours after hospital admission for exacerbation of COPD)	Spectrum of VOC in exhaled air in patients with COPD compared to those of control subjects. It is measured with a portable mass spectrometer system.

Secondary Outcome Measures

Name	Time	Method
Variation in VOC spectrum in COPD patients measured with a portable mass spectrometer system	3 months after hospital discharge	Variation in VOC spectrum in COPD patients during exacerbation and in stable condition (3 months later). It is measured with a portable mass spectrometer system.

Trial Locations

Locations (1)

CHU de SAINT-ETIENNE; 🇫🇷 Saint-etienne, France