NCT01575288已完成不适用
Oral Trehalose Therapy to Reverse Arterial Aging in Middle-Aged and Older Adults
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 110
- 试验地点
- 1
- 主要终点
- Arterial Stiffness
研究概览
简要总结
The proposed study will assess the ability of a naturally occurring sugar to improve the function of arteries with age. Overall, the proposed research project has the long-term potential to influence clinical practice guidelines by establishing a novel, easy to deliver, cost-effective therapy for treating age-associated arterial dysfunction and reducing the risk of cardiovascular disease with age.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 50 Years 至 79 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •women must be postmenopausal
- •body mass index (BMI) <40 kg/m2
- •weight stable in the prior 3 months
- •absence of clinical disease as determined by medical history, physical examination, blood and urine chemistries, ankle-brachial index, and a graded exercise stress test with monitoring of blood pressure and 12-lead ECG
排除标准
- 未提供
研究组 & 干预措施
Maltose
Placebo Comparator
干预措施: Placebo (Drug)
High-dose trehalose
Experimental
干预措施: High-dose trehalose (Drug)
结局指标
主要结局
Arterial Stiffness
时间窗: 12 weeks
Arterial pulse wave velocity
nitric-oxide mediated endothelium-dependent dilation
时间窗: 12 weeks
flow-mediated dilation and forearm blood flow responses to acetylcholine in the presence and absence of N'-monomethyl-L-arginine
次要结局
- Endothelial cell autophagic flux(12 weeks)
- Systemic oxidative stress and inflammation(12 weeks)
- Insulin sensitivity(12 weeks)
- Endothelial cell oxidative stress and inflammation(12 weeks)
研究者
研究点 (1)
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