The Role of Gastric Content Microaspirations in the Pathogenesis of Idiopathic Pulmonary Fibrosis

• Conditions: IDIOPATHIC PULMONARY FIBROSIS

• Registration Number: NCT01714934
• Lead Sponsor: Sheba Medical Center

Brief Summary

The pathogenesis of idiopathic pulmonary fibrosis (IPF) is debatable. Looking for an insult to lung parenchyma that generates the pathogenesis of the disease is challenging. Pepsin is a proteolytic enzyme present in the gastric juice. Microaspirations of gastric content were described as a potential factor for injury in many chronic lung disorders. Bronchoalveolar lavage (BAL) is a routine investigation technique in interstitial lung diseases. The presence of pepsin in the BAL fluid recovered from patients with IPF may indicate a possible role for gastric microaspirations in the pathogenesis of the disease.

Detailed Description

Not available

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Status Verified: 2012-10
• Study First Submitted: 2012-10-23
• Study First Submitted QC: 2012-10-25
• Last Update Submitted: 2012-10-25
• Study First Posted: 2012-10-26
• Last Update Posted: 2012-10-26
• Study Start: 2013-01
• Primary Completion: 2014-06
• Study Completion: 2014-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• patients with interstitial lung disorders including IPF

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Exclusion Criteria

• patients younger than 18 years or older than 85,
• pregnant women,
• patients that present with medical conditions contra -indicated for performing bronchoscopy including sedation

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
BAL Pepsin level	18 MONTHS

Trial Locations

Locations (1)

Sheba Medical Center; 🇮🇱 Ramat Gan, Israel