Assessing Taste Thresholds and Scores on Standardised Mood Questionnaires in Participants Without Mood Disorders
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Sweet taste threshold
研究概览
简要总结
The sweet threshold (concentration of sucrose in water) at which healthy participants can detect a sweet flavour will be recorded.
详细描述
The sweet threshold (concentration of sucrose in water) at which healthy participants can detect a sweet flavour will be recorded by means of application on a cotton bud to the anterior third of the tongue. Solutions will be presented in a pseudo-randomised order. Mood questionnaires will be completed (to check that participants are indeed healthy). The questionnaires used will be the Patient Health Questionnaire 9 (PHQ9), Beck's Depression Inventory (BDI) and Generalised Anxiety Disorder Questionnaire 7 (GAD-7).
This data is being collected with the intention of its use for comparison with sweet thresholds established in other populations using the same method of sweet threshold estimation.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •. Male and female adults of 18 years old and over;
- •Participants without a diagnosis of major depressive disorder (MDD) / anxiety disorder;
- •Participants not taking an antidepressant during the preceding 6 months
- •Not suffering from significant other mental or physical illness, such as confirmed psychosis, end of life care, or any other condition assessed as significant by the Site Investigator;
- •Willing and able to comply with all study-related procedures;
- •Not having COVID 19 or continuing effects of COVID 19 including altered sense of taste;
- •Understands the study requirements and the treatment procedures and is able to provide written informed consent.
排除标准
- •Taking antidepressant medication currently or during the previous 6 months;
- •Known or suspected hypersensitivity or intolerance to any taste testing solutions, or any of their excipients;
- •A history or presence of neurological or confounding psychiatric conditions (such as stroke, traumatic brain injury, epilepsy, space occupying lesions, multiple sclerosis, Parkinson's disease, vascular dementia, transient ischemic attack, or schizophrenia);
- •Patients with a diagnosis of chronic pain;
- •Pregnancy or possibility pregnancy, or breastfeeding;
- •Participants using supplements containing psychoactive herbs (for example St Johns Wort or 5-HTP (5-Hydroxytryptophan, also known as oxitriptan);
- •Participants regularly using psychoactive stimulants (for example MDMA);
- •Participants unable or unwilling to comply with study procedures.
研究组 & 干预措施
Healthy volunteers
Adults with no mood disorder and who have not been diagnosed with or had treatment for a mood disorder in the last 6 months.
结局指标
主要结局
Sweet taste threshold
时间窗: From enrolment to a final taste test 6 weeks later
Sweet taste threshold established by applying varying concentrations of sucrose solution to the tongue and assessing whether a sweet taste can be detected by the participant. The sweet threshold is the minimum concentration at which a participant can reliably detect the sweet flavour.
次要结局
- Score on Becks Depression Inventory(From enrolment to a final questionnaire 6 weeks later)
- Score on Patient Health Questionnaire 9(From enrolment to a final questionnaire 6 weeks later)
- Score on Generalised Anxiety Disorder scale 7(From enrolment to a final questionnaire 6 weeks later)