the New Biomarker of the Knee Osteoarthritis Knee Osteoarthritis Occurrence and Progression
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 460
- 主要终点
- Serum levels of Transforming Growth Factor Beta1 (TGF-β1) and Platelet Derived Growth Factor BB (PDGF-BB) may be novel biomarkers in knee osteoarthritis
研究概览
简要总结
It was previously proved an association of TGF-β1 and PDGF-BB with the pathogenesis of osteoarthritis (OA) by experiments of OA animal models. In this study, we aimed to determine whether serum concentrations of TGF-β1, PDGF-BB and CTX-1 were related to the knee OA. knee OA cases were collected from the first affiliated hospital of Shihezi university and healthy controls were recruited from the community. The severity of knee OA was defined as kellgren-lawrence (K-L) classification criteria.Serum levels of chemical biomarkers were compared between knee OA cases and controls or among K-L grade 2 to grade 4 groups. The serum concentrations of the TGF-β1, PDGF-BB and CTX-1 were determined by ELISA .
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 38 Years 至 78 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •OA diagnosis was on the basis of the diagnosis and treatment guideline of the American Academy of Orthopedic Surgeons
排除标准
- •Participants who met the following criteria were excluded：
- •the knee OA concomitant with hip OA,
- •suppurative and rheumatoid arthritis,
- •gout patients,
- •patients who underwent knee arthroscopy surgery within 6 months,
- •bilateral or unilateral knee replacements,
- •the knee joint trauma patients,
- •histories of glucocorticoid and/or sterol hormones.
结局指标
主要结局
Serum levels of Transforming Growth Factor Beta1 (TGF-β1) and Platelet Derived Growth Factor BB (PDGF-BB) may be novel biomarkers in knee osteoarthritis
时间窗: 3 years
次要结局
未报告次要终点
研究者
Jianwei He
Principal investigator
Shihezi University